{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:47:56Z","timestamp":1782467276691,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00d3n Cient\u00cdfica y Tecnol\u00d3gica","doi-asserted-by":"publisher","award":["PID 2016\u20100020"],"award-info":[{"award-number":["PID 2016\u20100020"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00d3n Cient\u00cdfica y Tecnol\u00d3gica","doi-asserted-by":"publisher","award":["PICT\u20102020\u2010SERIEA\u201002159"],"award-info":[{"award-number":["PICT\u20102020\u2010SERIEA\u201002159"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hepatitis E virus (HEV) is a recognized cause of acute hepatitis and a potential trigger of acute decompensation (AD) and acute\u2010on\u2010chronic liver failure (ACLF) in patients with cirrhosis in hyperendemic regions; however, its clinical relevance in low\u2010endemic settings remains poorly defined. We conducted a combined cross\u2010sectional and prospective longitudinal study to evaluate the prevalence and clinical impact of HEV infection among patients with cirrhosis in Argentina. Adult patients with mild\u2010to\u2010moderate cirrhosis (Child\u2013Pugh score 6\u201312) of different etiologies were tested for anti\u2010HEV IgG and IgM antibodies by ELISA and HEV RNA by RT\u2010PCR in serum samples. Epidemiological data were collected using a structured questionnaire. In the longitudinal cohort, patients were followed for up to 24 months with serial sampling at baseline, every 6 months, and during episodes of hepatic decompensation. Anti\u2010HEV IgG seroprevalence was 5.2% (95% CI: 2.2\u201311.5%), comparable to that observed in healthy blood donors, with no significant differences across cirrhosis etiologies. No patient had detectable anti\u2010HEV IgM or HEV RNA at baseline. During follow\u2010up, 19 patients developed hepatic decompensation, including six cases of ACLF; three patients showed anti\u2010HEV IgG positivity, including one seroconversion, but none had evidence of acute HEV infection. These findings indicate limited HEV exposure among patients with cirrhosis in this low\u2010endemic region and suggest that HEV infection is unlikely to represent a major trigger of AD or ACLF, although continued surveillance remains warranted.<\/jats:p>","DOI":"10.1002\/jmv.70988","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T06:20:56Z","timestamp":1779949256000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hepatitis E Virus Infection as a Trigger of Hepatic Decompensation: A Single\u2010Center Prospective and Cross\u2010Sectional Study From Rosario, Argentina"],"prefix":"10.1002","volume":"98","author":[{"given":"Juli\u00e1n","family":"Acosta","sequence":"first","affiliation":[{"name":"Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Instituto de Biolog\u00eda Molecular y Celular de Rosario\u2010CONICET Universidad Nacional de Rosario Rosario Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alceo","family":"Galimberti","sequence":"additional","affiliation":[{"name":"Hospital Provincial del Centenario\/Facultad de Ciencias M\u00e9dicas, Servicio de Gastroenterolog\u00eda y Hepatolog\u00eda Universidad Nacional de Rosario Rosario Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8569-8123","authenticated-orcid":false,"given":"Fernando","family":"Bessone","sequence":"additional","affiliation":[{"name":"Hospital Provincial del Centenario\/Facultad de Ciencias M\u00e9dicas, Servicio de Gastroenterolog\u00eda y Hepatolog\u00eda Universidad Nacional de Rosario Rosario Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Tanno","sequence":"additional","affiliation":[{"name":"Hospital Provincial del Centenario\/Facultad de Ciencias M\u00e9dicas, Servicio de Gastroenterolog\u00eda y Hepatolog\u00eda Universidad Nacional de Rosario Rosario Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Gardiol","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Instituto de Biolog\u00eda Molecular y Celular de Rosario\u2010CONICET Universidad Nacional de Rosario Rosario Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Virginia","family":"Reggiardo","sequence":"additional","affiliation":[{"name":"Hospital Provincial del Centenario\/Facultad de Ciencias M\u00e9dicas, Servicio de Gastroenterolog\u00eda y Hepatolog\u00eda Universidad Nacional de Rosario Rosario Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1414-369X","authenticated-orcid":false,"given":"Ana Laura","family":"Cavatorta","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Instituto de Biolog\u00eda Molecular y Celular de Rosario\u2010CONICET Universidad Nacional de Rosario Rosario Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.86"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/v15061389"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a031880"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/v8090253"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11050456"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2022.109618"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18040869"},{"key":"e_1_2_10_9_1","first-page":"1","article-title":"Update: Proposed Reference Sequences for Subtypes of Hepatitis E Virus (Species Orthohepevirus A)","volume":"1","author":"Smith D. 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