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Although viral miRNAs have been extensively explored as diagnostic tools, the clinical relevance of host miRNAs dysregulation across EBV\u2010associated malignancies, particularly as a unified indicator of tumor progression, remains unclear. In this cross\u2010sectional study, we analyzed plasma from 60 DLBCL patients and 233 NPC patients, along with matched tumor tissues from 20 NPC cases, and uncovered a consistent two\u2010miRNA signature in circulation: hsa\u2010miR\u20107\u20105p was progressively downregulated, while hsa\u2010miR\u2010210\u20103p was upregulated, in parallel with advancing clinical stage and metastatic burden. The inverse expression pattern was recapitulated in NPC tumor tissues by in situ hybridization, confirming its biological relevance at the lesion site. Notably, the association between this miRNA signature and disease severity was markedly more pronounced in EBV\u2010positive tumors than in EBV\u2010negative counterparts. Together, our data suggest that circulating hsa\u2010miR\u20107\u20105p and hsa\u2010miR\u2010210\u20103p form a clinically informative, host\u2010derived signature that tracks with tumor aggressiveness, and may offer a potential practical, non\u2010invasive means to monitor disease progression of multiple EBV\u2010associated cancers.<\/jats:p>","DOI":"10.1002\/jmv.70990","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T05:59:53Z","timestamp":1779861593000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Host miRNA Signature Correlates With Clinical Stage Across Epstein\u2010Barr Virus\u2010Associated Malignancies"],"prefix":"10.1002","volume":"98","author":[{"given":"Yifei","family":"Xu","sequence":"first","affiliation":[{"name":"MOE\/NHC\/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infections Disease and Biosecurity, Shanghai Frontiers Science 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