{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:23:44Z","timestamp":1790457824748,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Human adenovirus (HAdV)\u2212114 (P7H3F3) is a newly identified recombinant genotype, while recent studies suggest that it likely represents a previously circulating HAdV\u20103 strain. A total of 413 strains previously identified as HAdV\u20103 from 20 Chinese provinces during 2000\u20132024, along with 125 GenBank\u2010derived HAdV\u20103 strains (1988\u20132023), underwent genotype reconfirmation and genetic evolutionary analysis using the penton base, hexon, and fiber genes. Furthermore, 97 representative strains were selected for whole\u2010genome analysis to determine their genetic recombination patterns. Of the 538 analyzed strains, 537 were identified as HAdV\u2010114 using three genes, with only one 2010 U.S strain classified as HAdV\u20103. Phylogenetic analysis revealed three HAdV\u2010114 clades (Clades 1\u20133): Clade 1 (1988\u20132019) displayed sporadic circulation, Clade 2 (2023\u20132024) appeared geographically restricted to three Chinese provinces, and Clade 3 (2000\u20132024) likely represented the globally dominant strain. Genetic evolutionary analyses indicated that, although HAdV\u2010114 originated from recombination between HAdV\u20107 and HAdV\u20103, its three Clades diverged from the parental trajectories, with Clades 1 and 3 sharing a common evolutionary origin and Clade 2 forming an independent terminal cluster. Genomic recombination analysis identified two recombination patterns across the three clades. All clades shared a 3\u2032 terminal genomic region (nt 18,794\u2013end) derived from HAdV\u20103, whereas their 5\u2032 ends comprised gene fragments recombined from unknown sources and epidemic HAdV\u20107 strains, with varied breakpoints. HAdV\u2010114, historically identified as HAdV\u20103, is the predominant genotype associated with HAdV\u2010related respiratory infections. Therefore, enhanced surveillance of recombinant HAdV strains is imperative for effective disease control.<\/jats:p>","DOI":"10.1002\/jmv.70993","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:52:10Z","timestamp":1780048330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genomic Analysis Reveals Dominance of Human Adenovirus Genotype B114 Among Circulating Strains Historically Identified as B3"],"prefix":"10.1002","volume":"98","author":[{"given":"Chongyang","family":"Li","sequence":"first","affiliation":[{"name":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Jin","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Virus Disease Prevention and Control Institute, Shaanxi Provincial Center for Disease Control and Prevention Xian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daxing","family":"Feng","sequence":"additional","affiliation":[{"name":"Section of EPI, Henan Provincial Center for Disease Control and Prevention Zhengzhou 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