{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:48:01Z","timestamp":1782467281292,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cervical cancer remains a major public health concern in Sarawak, East Malaysia, which reports the highest incidence in the country. Prophylactic human papillomavirus (HPV) vaccination programme currently uses bivalent (2\u2009v) and quadrivalent (4\u2009v) vaccines targeting HPV16 and 18 (and additional low\u2010risk HPV6 and 11 for 4\u2009v). However, the alignment of these vaccines with locally circulating high\u2010risk HPV (hrHPV) genotypes is poorly understood. We conducted a serial cross\u2010sectional study involving 1,108 women in Sarawak, Malaysia from 2018 to 2024. Self\u2010collected high vaginal swabs were analyzed using the Anyplex\u2122 II HPV HR Detection Kit for 14 hrHPV genotypes. Demographic data and vaccination status were collected. Descriptive statistics and Chi\u2010square tests were used to evaluate associations between hrHPV positivity and demographic variables. The overall hrHPV prevalence was 10.2% (95% CI: 8.6\u201312.1%). Among positive cases, 87.6% had single, 10.6% dual, and 1.8% triple genotype infections. The most frequent genotypes were HPV18 (19.2%), HPV52 (16.9%), HPV39 (14.6%), and HPV51 (10.0%). Genotypes covered by the 2\u2009v\/4\u2009v vaccines (HPV16\/18) accounted for 25.4% of infections, and those included in the nonavalent (9\u2009v) vaccine extended coverage to 56.2%. Notably, 43.8% of infections were due to non\u20102v\/4\u2009v\/9\u2009v vaccine genotypes. No significant associations were found between HPV positivity and age group, ethnicity, geographic division, or vaccination status. Our findings indicate a mismatch between current HPV vaccines and the prevalent hrHPV genotypes in Sarawak. While the 9\u2009v vaccine offers improved coverage, a substantial proportion of infections are due to non\u2010vaccine types. Strengthening molecular surveillance, improving access to screening, and addressing vaccine\u2010derived complacency are critical to achieving cervical cancer elimination in this region.<\/jats:p>","DOI":"10.1002\/jmv.71010","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T07:06:33Z","timestamp":1782111993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mismatch Between Vaccine Targets and Endemic HPV Genotypes in Sarawak, East Malaysia: Implications for Cervical Cancer Prevention"],"prefix":"10.1002","volume":"98","author":[{"given":"Abigail Rembui","family":"Jerip","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences Universiti Malaysia Sarawak Kota Samarahan Malaysia"},{"name":"Pink and Teal Empowher Kuching Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaenessa","family":"Noni","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences Universiti Malaysia Sarawak Kota Samarahan Malaysia"},{"name":"Pink and Teal Empowher Kuching Malaysia"},{"name":"Department of Paraclinical Sciences, Faculty of Medicine and Health Sciences Universiti Malaysia Sarawak Kota Samarahan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3601-7582","authenticated-orcid":false,"given":"Ahmad Asyraf","family":"Senian","sequence":"additional","affiliation":[{"name":"Department of Paraclinical Sciences, Faculty of Medicine and Health Sciences Universiti Malaysia Sarawak Kota Samarahan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2607-1177","authenticated-orcid":false,"given":"Andy Cheong Shin","family":"Bong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences Universiti Malaysia Sarawak Kota Samarahan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaria","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences Universiti Malaysia Sarawak Kota Samarahan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor Tini","family":"Sidik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences Universiti Malaysia Sarawak Kota Samarahan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awi","family":"Idi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences Universiti Malaysia Sarawak Kota Samarahan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee Yee","family":"Kyaing","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences Universiti Malaysia Sarawak Kota Samarahan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dzuriaty","family":"Siri\u2010ee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences Universiti Malaysia Sarawak Kota Samarahan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siti Fairouz","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Paraclinical Sciences, Faculty of Medicine and Health Sciences Universiti Malaysia Sarawak Kota Samarahan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6312-4551","authenticated-orcid":false,"given":"Cheng Siang","family":"Tan","sequence":"additional","affiliation":[{"name":"Pink and Teal Empowher Kuching Malaysia"},{"name":"Department of Paraclinical Sciences, Faculty of Medicine and Health Sciences Universiti Malaysia Sarawak Kota Samarahan Malaysia"},{"name":"Therapeutic Research Centre, Faculty of Medicine and Health Sciences Universiti Malaysia Sarawak Kota Samarahan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"A.Manan H.Basri N.Kaur et al. 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[cited 2025 Dec 24] https:\/\/portlandpress.com\/clinsci\/article\/131\/17\/2201\/71573\/The-human-papillomavirus-replication-cycle-and-its(accessed 2025 Dec 24).","DOI":"10.1042\/CS20160786"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.20892\/J.ISSN.2095-3941.2020.0370"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-018-6316-6"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12879-025-10520-6"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/VACCINES8030391"},{"key":"e_1_2_12_14_1","unstructured":"World Health Organization. Global Strategy to Accelerate the Elimination of Cervical Cancer as a Public Health Problem. 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[cited 2025 Jun 20] https:\/\/codeblue.galencentre.org\/2024\/03\/all-form-one-girls-from-2022-and-2023-cohorts-missed-hpv-vaccination\/(accessed 2025 Jun 20)."},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/FPUBH.2024.1357073"},{"key":"e_1_2_12_23_1","unstructured":"Human Papillomavirus and Related Diseases in Malaysia. Summary Report [Internet]. 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