{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:48:00Z","timestamp":1782467280084,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The COVID\u201019 pandemic and its associated nonpharmaceutical interventions (NPIs) dramatically altered influenza epidemiology. This study aimed to characterize the post\u2010pandemic influenza resurgence in Guangzhou, China, and explore the interplay between NPIs, SARS\u2010CoV\u20102 infections, and influenza activity. We conducted a retrospective analysis of 73\u2009652 patients with flu\u2010like symptoms at a major tertiary hospital in Guangzhou between February 2016 and June 2024. Cases were stratified by age and period (pre\u2010pandemic, pandemic, post\u2010pandemic). We compared influenza positivity rates via rapid antigen tests and analyzed hematological parameters (WBC, neutrophil, lymphocyte counts) in influenza\u2010positive patients. Influenza positivity rates plummeted during the pandemic (1.99%) compared to pre\u2010pandemic levels (10.20%). However, a dramatic surge occurred in the first post\u2010pandemic year, reaching 24.96%. Influenza A rebounded earlier and more intensely than influenza B. Adults (\u2265\u200918 years) exhibited a significantly greater percent increase in positivity rates compared to children and showed more pronounced decreases in WBC and neutrophil counts post\u2010pandemic. Lymphocyte counts initially increased but later declined. The post\u2010pandemic influenza surge in Guangzhou was both prolonged and intense, likely driven by a dual mechanism: an \u201cimmunity gap\u201d created by prolonged NPIs and potential immune alterations following widespread SARS\u2010CoV\u20102 infection. Sustained vaccination and proactive public health measures are crucial for managing future respiratory virus threats.<\/jats:p>","DOI":"10.1002\/jmv.71012","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T06:46:39Z","timestamp":1781160399000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Post\u2010Pandemic Influenza Resurgence in Guangzhou, China: Impact of COVID\u201019 Interventions and Immune Alterations"],"prefix":"10.1002","volume":"98","author":[{"given":"Jiankai","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuping","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Bobai County People's Hospital Yulin 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