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This study was the first to investigate the frequency of HTLV\u20101 and its molecular diversity among patients with hematolymphoid cancers who were treated at a leading reference hospital in Par\u00e1, northern Brazil. For this purpose, information from the International Classification of Diseases (ICD), laboratory test records, and peripheral blood samples were obtained. Patients with confirmed diagnosis of leukemia\/lymphoma, myeloma, other hematological malignancies, and those under diagnostic investigation were included in the study. Serological screening for anti\u2010HTLV\u20101\/2 antibodies was carried out by ELISA, and infection was confirmed by real\u2010time PCR. PCR\u2010positive samples were sequenced for phylogenetic analysis. Of 329 people assessed, 47.7% were men (157) and 52.3% were women (172). The overall prevalence of HTLV\u20101 was 1.82% (6\/329), with 2.5% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20094) in men and 1.2% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092) in women. Phylogenetic analysis of the 5\u2032LTR region (715\u2009bp) of HTLV\u20101 indicated that the isolates belonged to the Cosmopolitan subtype, Transcontinental subgroup. Positivity among patients with lymphoma was 6.56% (4\/61), with one patient diagnosed with Hodgkin lymphoma. Among patients under clinical investigation and with other types of cancer, the prevalence of infection was 1.19% (1\/84) and 2.38% (1\/42), respectively. A decrease in red blood cell count, hemoglobin, and hematocrit was identified in cancer patients with a negative HTLV diagnosis compared to HTLV\u2010positive patients. Our results highlight the importance of including HTLV\u20101\/2 testing in the routine follow\u2010up of cancer patients, for the sake of existing successful treatment protocols.\n                  <\/jats:p>","DOI":"10.1002\/jmv.71024","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T12:28:03Z","timestamp":1783600083000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular and Phylogenetic Characterization of HTLV\u20101 Infection in Patients With Hematological Malignancies in the State of Par\u00e1, Northern Brazil"],"prefix":"10.1002","volume":"98","author":[{"given":"Gabriel dos Santos Pereira","family":"Neto","sequence":"first","affiliation":[{"name":"Laboratory of Virology, Institute of Biological Sciences Federal University of Par\u00e1 Bel\u00e9m Brazil"},{"name":"Postgraduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences 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