{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:47:49Z","timestamp":1782467269574,"version":"3.54.5"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The SARS\u2010CoV\u20102 virus continues to evolve under immune selection pressure, leading to the emergence of antigenically distinct Omicron subvariants such as BA.3.2.2. This sublineage harbors extensive spike mutations, including numerous substitutions within the receptor\u2010binding domain, suggesting potential immune escape from currently deployed vaccines. Given its increasing prevalence, we evaluated the neutralization capacity of variant\u2010adapted vaccines against BA.3.2.2. Using Ad5\/35\u2010based adenoviral vaccines encoding JN.1 and LP.8.1 spike antigens, neutralizing antibody responses were assessed in murine and non\u2010human primate models using a pseudotyped lentivirus assay. Antigenic cartography based on neutralization data demonstrated that BA.3.2.2 is antigenically distant from previously circulating variants. Although LP.8.1 vaccination broadened neutralization against multiple variants, neutralizing activity against BA.3.2.2 was markedly lower than that against LP.8.1 and other tested variants. Booster immunization further enhanced responses to matched variants but failed to restore neutralization against BA.3.2.2. These findings indicate that BA.3.2.2 exhibits substantial resistance to vaccine\u2010induced neutralization, underscoring the urgent need for updated vaccine strategies to address newly emerging SARS\u2010CoV\u20102 variants.<\/jats:p>","DOI":"10.1002\/jmv.71025","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T09:10:41Z","timestamp":1781687441000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Limited Cross\u2010Neutralization of Emerging SARS\u2010CoV\u20102 BA.3.2.2 After LP.8.1\u2010Updated Vaccination"],"prefix":"10.1002","volume":"98","author":[{"given":"Soojeong","family":"Chang","sequence":"first","affiliation":[{"name":"Research &amp; Development Center, Cellid Co. Ltd. Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieun","family":"Shin","sequence":"additional","affiliation":[{"name":"Research &amp; Development Center, Cellid Co. Ltd. Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seowoo","family":"Park","sequence":"additional","affiliation":[{"name":"Research &amp; Development Center, Cellid Co. Ltd. Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyemin","family":"Park","sequence":"additional","affiliation":[{"name":"Research &amp; Development Center, Cellid Co. Ltd. Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bongju","family":"Park","sequence":"additional","affiliation":[{"name":"Research &amp; Development Center, Cellid Co. Ltd. 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Seoul Republic of Korea"},{"name":"Research Institute of Pharmaceutical Science, College of Pharmacy Seoul National University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Green","family":"Kim","sequence":"additional","affiliation":[{"name":"National Primate Research Centre Korea Research Institute of Bioscience and Biotechnology (KRIBB) Cheongju Chungcheongbuk Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Ho","family":"Baek","sequence":"additional","affiliation":[{"name":"National Primate Research Centre Korea Research Institute of Bioscience and Biotechnology (KRIBB) Cheongju Chungcheongbuk Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Joo","family":"Hong","sequence":"additional","affiliation":[{"name":"National Primate Research Centre Korea Research Institute of Bioscience and Biotechnology (KRIBB) Cheongju Chungcheongbuk Republic of Korea"},{"name":"KRIBB School of Bioscience Korea University of Science &amp; Technology (UST) Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Yuil","family":"Kang","sequence":"additional","affiliation":[{"name":"Research &amp; Development Center, Cellid Co. 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