{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:48:10Z","timestamp":1782467290940,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>This study aimed to assess the humoral immune response following administration of a BNT162b2 mRNA COVID\u201019 booster dose and to evaluate its association with the development of SARS\u2010CoV\u20102 infection after vaccination. Between July 2021 and February 2022, serum samples were collected from 313 individuals 28 days after receiving a COVID\u201019 booster dose. Quantitative SARS\u2010CoV\u20102 IgG antibodies directed against the receptor\u2010binding domain (RBD) of the spike protein were measured using a chemiluminescent microparticle immunoassay. Neutralizing antibody activity, defined as inhibition of the RBD\u2013ACE2 interaction, was evaluated semi\u2010quantitatively by a competitive ELISA. Participants were followed for 6 months after the final dose to identify confirmed SARS\u2010CoV\u20102 infections. The cohort included 97 males (31%) and 216 females (69%), with a mean age of 39.43 years. The median SARS\u2010CoV\u20102 IgG antibody level at day 28 was 7713.3\u2009AU\/mL, and the median neutralizing antibody inhibition rate was 99.2%. Antibody levels were not significantly associated with age or comorbidities. Booster vaccination induced a strong humoral immune response in all participants. However, the occurrence of post\u2010vaccination infections despite high antibody levels suggests immune escape by emerging variants. While vaccines may not fully prevent infection, they provide substantial protection against severe disease and mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.71026","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:24:38Z","timestamp":1781796278000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Booster mRNA Vaccination Prevents Breakthrough Severe COVID\u201019 Infections"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3628-7392","authenticated-orcid":false,"given":"Harika \u00d6yk\u00fc","family":"Din\u00e7","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine \u00dcsk\u00fcdar University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2476-3796","authenticated-orcid":false,"given":"Hayriye 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