{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:40:14Z","timestamp":1784004014964,"version":"3.55.0"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/W010755\/1"],"award-info":[{"award-number":["BB\/W010755\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Crimean\u2010Congo hemorrhagic fever virus (CCHFV) is a segmented RNA virus that can cause severe hemorrhagic fever and is primarily transmitted to humans and other mammals through tick bites. Since segment reassortment can increase genetic diversity and disease severity, we sampled infected ticks and humans in Sivas Province, T\u00fcrkiye, a region with high CCHFV prevalence. Analysis of 113 human and 23 Hyalomma tick CCHFV samples revealed three main phylogenetic clades in Sivas. The most common clade (SIVAS\u20102) was involved in multiple reassortants. Phylogenetic analysis indicated multiple independent reassortment events involving all three CCHFV genome segments. The most common reassortant (1.1.2) was detected only in the Zara district of Sivas in both humans and ticks. We found that most infections were geographically limited to local spread and that infections with more than one variant and reassortment were exceptional. We found no significant clinical differences between human SIVAS\u20101, SIVAS\u20102 and the 1.1.2 reassortant infections. Thus, within the limits of the available sample size, we found no evidence that the two parental forms differed in disease severity or that the 1.1.2 reassortant was associated with increased severity. Continued CCHFV surveillance could uncover future forms of the virus with altered characteristics.<\/jats:p>","DOI":"10.1002\/jmv.71027","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T07:11:11Z","timestamp":1782112271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multiple Reassortments, Limited Geographic Spread, and Comparable Pathogenicity of Crimean\u2010Congo Hemorrhagic Fever Viruses in Sivas Province, T\u00fcrkiye"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8620-9910","authenticated-orcid":false,"given":"Qianying","family":"Lin","sequence":"first","affiliation":[{"name":"Theoretical Biology and Biophysics Los Alamos National Laboratory Los Alamos NM USA"},{"name":"Division of Biostatistics The Ohio State University Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazif","family":"Elaldi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Cumhuriyet University Sivas Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8127-3419","authenticated-orcid":false,"given":"Mesut","family":"Yigit","sequence":"additional","affiliation":[{"name":"Department of Parasitology Kafkas University Kars Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baris","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Life Sciences and Technology Application and Research Center Kafkas University Kars Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Hewson","sequence":"additional","affiliation":[{"name":"Virology and Pathogenesis UKHSA Porton Down Salisbury UK"},{"name":"Department of Infection Biology London School of Hygiene and Tropical Medicine London UK"},{"name":"Wellcome Sanger Institute Hinxton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn","family":"L\u00f3pez\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"School of Mathematics University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Lythe","sequence":"additional","affiliation":[{"name":"School of Mathematics University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse Nur","family":"Pektas","sequence":"additional","affiliation":[{"name":"Cumhuriyet University Advanced Technology Application and Research Center (CUTAM) Cumhuriyet University Sivas Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binnur","family":"Koksal","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics Cumhuriyet University Sivas Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuba Nur","family":"Tasseten","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Cumhuriyet University Sivas Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Deniz","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine Kafkas University Kars Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilal","family":"Bedir","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine Kafkas University Kars Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasemin Cakir","family":"Kiymaz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Cumhuriyet University Sivas Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zati","family":"Vatansever","sequence":"additional","affiliation":[{"name":"Department of Parasitology Kafkas University Kars Turkiye"},{"name":"Life Sciences and Technology Application and Research Center Kafkas University Kars Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Molina\u2010Par\u00eds","sequence":"additional","affiliation":[{"name":"Theoretical Biology and Biophysics Los Alamos National Laboratory Los Alamos NM USA"},{"name":"School of Mathematics University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Leitner","sequence":"additional","affiliation":[{"name":"Theoretical Biology and Biophysics Los Alamos National Laboratory Los Alamos NM USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010855"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.80974-0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.07.006"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20106"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2009.10.014"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2009.0247"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.014878-0"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20120097"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70435-2"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid3101.241264"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.80121-0"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ympev.2010.01.006"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2011.0770"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00752-06"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2010.06.010"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.37871\/jbres2058"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1008.030928"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2008.07.021"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2015.12.003"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2007.0134"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006248"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2017.11.027"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00644-06"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2009.11.009"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166744"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid3004.231155"},{"issue":"4","key":"e_1_2_10_28_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0014204","article-title":"Genomic Characterisation of Crimean\u2010Congo Haemorrhagic Fever Virus (CCHFV) in Tajikistan Identifies a Novel Reassortant Virus","volume":"20","author":"D'Addiego J.","year":"2026","journal-title":"PLOS Neglected Tropical Diseases"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2020.101622"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2009.06.018"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2011.0896"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-014-2238-0"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1616068"},{"key":"e_1_2_10_34_1","volume-title":"Ticks of Europe and North Africa: A Guide to Species Identification","author":"Estrada\u2010Pe\u00f1a A.","year":"2018"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28548"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.15"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1089\/cmb.2012.0021"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt086"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/ve\/vey007"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143081"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkf436"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/sysbio\/syq010"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/2041-210X.12628"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0013752"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1995.11.1413"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12075"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2023.114833"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2018.07.010"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1214\/aoms\/1177730491"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2397-2335.1922.tb00768.x"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002864"},{"key":"e_1_2_10_52_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2021"},{"issue":"3","key":"e_1_2_10_53_1","first-page":"908","article-title":"Package \u2018ggcorrplot\u2019","volume":"3","author":"Kassambara A.","year":"2019","journal-title":"R package version 0.1"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2020.101448"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02448-05"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002647"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110982"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.71027","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.71027","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.71027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:18:56Z","timestamp":1782465536000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.71027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/jmv.71027"],"URL":"https:\/\/doi.org\/10.1002\/jmv.71027","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2026-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71027"}}