{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:48:06Z","timestamp":1782467286855,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tocilizumab, an interleukin\u20106 receptor antagonist, has been widely used in the management of severe COVID\u201019 cases, but its clinical outcomes have been variable. A retrospective cohort including 113 hospitalized adult patients with confirmed COVID\u201019 treated with tocilizumab between March and October 2021 at a private hospital in southern Brazil. Demographic, clinical, and laboratory variables were collected at four time points: admission, 72\u2009h before tocilizumab administration, 72\u2009h after, and at hospital discharge or death. The median age was significantly higher among non\u2010survivors (73.0 vs. 58.5 years;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Cardiovascular, metabolic, pulmonary, and neoplastic comorbidities negatively impacted clinical outcomes. These patients also showed persistent elevation of inflammatory markers and organ dysfunction indicators, such as\n                    <jats:sc>d<\/jats:sc>\n                    \u2010dimer, urea, and BNP. Concomitant use of corticosteroids was associated with improved survival (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04). Age, comorbidities, and persistent elevation of inflammatory markers were associated with worse prognosis in patients treated with tocilizumab. Concomitant use of corticosteroids demonstrated a potential benefit, suggesting a synergistic effect between the therapies. These findings underscore the importance of laboratory monitoring and individualized therapeutic approaches in severe COVID\u201019.\n                  <\/jats:p>","DOI":"10.1002\/jmv.71028","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T06:10:57Z","timestamp":1782195057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Inflammatory Markers, Comorbidities, and Mortality in COVID\u201019 Patients Treated With Tocilizumab"],"prefix":"10.1002","volume":"98","author":[{"given":"Rafaela Munari da","family":"Silva","sequence":"first","affiliation":[{"name":"Escrit\u00f3rio de Gest\u00e3o da Pr\u00e1tica cl\u00ednica Hospital Moinhos de Vento Porto Alegre Rio Grande do Sul Brasil"},{"name":"Faculdade de Ci\u00eancias da Sa\u00fade Moinhos de Vento Porto Alegre Rio Grande do Sul Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio 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