{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:39:16Z","timestamp":1792463956981,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["INV\u2010021790"],"award-info":[{"award-number":["INV\u2010021790"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["20 1198 PjF 01 H"],"award-info":[{"award-number":["20 1198 PjF 01 H"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Accurate and comparable human papillomavirus (HPV) testing is essential for vaccine research, surveillance, and cervical cancer screening. Since 2008, the WHO HPV Laboratory Network has conducted global HPV proficiency testing traceable to International Standards. Here, we present a retrospective analysis of global HPV genotyping and screening proficiency panel results collected between 2008 and 2024. The HPV genotyping panel consists of 43 blinded samples including HPV6\/11, all oncogenic and vaccine\u2010targeted HPV types. A screening panel, launched in 2022, includes 13 blinded samples for cervical screening. Laboratories worldwide test panels using their methods, and results are evaluated at the International HPV Reference Center. Proficiency is defined as absence of false positives and detection of HPV16\/18 at 10\u2009IU\/\u00b5L, and other oncogenic types at 100\u2009IU\/\u00b5L (genotyping) or 1000\u2009IU\/\u00b5L (screening). Genotyping panel participation increased from 54 laboratories (2008) to &gt;\u2009130 (2021). Proficiency rose from ~25% to &gt;\u200980% by 2024, with &gt;\u200999% correct detection for most genotypes. Optional low\u2010copy challenges (1\u2009IU\/\u00b5L HPV16\/18) were detected by &gt;\u200995% of laboratories by 2024. Screening panel participation increased from 84 laboratories (2022) to 132 (2024), with proficiency improving from 77% to 95% and &gt;\u200996% datasets free of false positives. Annual HPV proficiency testing provides global laboratory quality assurance supporting cervical cancer elimination.<\/jats:p>","DOI":"10.1002\/jmv.71033","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:12:38Z","timestamp":1782738758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Global Performance of Human Papillomavirus Typing, Screening, and Evaluation As Assessed Using Proficiency Panels Traceable to International Standards: A Retrospective Analysis, 2008\u20132024"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2498-5206","authenticated-orcid":false,"given":"Laila Sara","family":"Arroyo M\u00fchr","sequence":"first","affiliation":[{"name":"International HPV Reference Center, Center for Cervical Cancer Elimination Karolinska Institutet and Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2368-7402","authenticated-orcid":false,"given":"Emel","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"International HPV Reference Center, Center for Cervical Cancer Elimination Karolinska Institutet and Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Lagheden","sequence":"additional","affiliation":[{"name":"International HPV Reference Center, Center for Cervical Cancer Elimination Karolinska Institutet and Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Eklund","sequence":"additional","affiliation":[{"name":"International HPV Reference Center, Center for Cervical Cancer Elimination Karolinska Institutet and Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joakim","family":"Dillner","sequence":"additional","affiliation":[{"name":"International HPV Reference Center, Center for Cervical Cancer Elimination Karolinska Institutet and Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.10.062"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2022-004197"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2024.105671"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.03.033"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00918-10"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.70022"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2023.105581"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2022.105237"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02453-13"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2018.01.016"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00840-12"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2021.104902"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2024.105660"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33519"},{"key":"e_1_2_10_16_1","unstructured":"International HPV Reference Center. Technical Report on the Global HPV LabNet DNA Genotyping Proficiency Panel 2017 accessed 6 June 2021https:\/\/www.hpvcenter.se\/wp-content\/uploads\/2021\/06\/Global-HPV-DNA-PP-2017-summary-report.pdf."},{"key":"e_1_2_10_17_1","unstructured":"International Agency for Research on Cancer (IARC). IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Biological agents. Volume 100 B. A review of human carcinogens. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans100 1\u2013441 (2012)."},{"key":"e_1_2_10_18_1","unstructured":"World Health Organization. WHO Meeting on the Standardization of HPV Assays and the Role of Who HPV Labnet in Supporting Vaccine Introduction. 2008. Meeting Report accessed 11 May 2025 https:\/\/cdn.who.int\/media\/docs\/default-source\/biologicals\/vaccine-quality\/who-meeting-on-the-standardization-of-hpv-assays-and-the-role-of-who-hpv-labnet-in-supporting-vaccine-introductione20d5b13-cf61-429f-88b3-5ba0ab41f445.pdf?download=true&sfvrsn=4163fbc9_1&utm_source=chatgpt.com."},{"key":"e_1_2_10_19_1","unstructured":"Digene Corporation. HC2 High\u2010Risk HPV DNA Test (Hybrid Capture\u00ae2) \u2013 Data Sheet\/5101\u20101296. U.S. Food and Drug Administration Office of Device Evaluation. 2002. Report No.: P890064\/S009 accessed 11 May 2025 https:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf\/p890064s009c.pdf."},{"key":"e_1_2_10_20_1","unstructured":"World Health Organization. Target Product Profiles for Human Papillomavirus Screening Tests to Detect Cervical Pre\u2010Cancer and Cancer. 2024. Geneva: WHO accessed 11 May 2025 https:\/\/www.who.int\/publications\/i\/item\/9789240100275."},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33033"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24010"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.70310"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-18455-3"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.71033","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.71033","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.71033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:54:27Z","timestamp":1792461267000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.71033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/jmv.71033"],"URL":"https:\/\/doi.org\/10.1002\/jmv.71033","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]},"assertion":[{"value":"2026-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71033"}}