{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:39:25Z","timestamp":1792463965026,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Ainuovirine (ANV) is a novel non\u2010nucleoside reverse transcriptase inhibitor used in China, but longitudinal real\u2010world evidence on its virological outcomes and trajectories of immunological, metabolic, hepatic, and renal parameters in treatment\u2010na\u00efve adults remains limited. In this single\u2010center longitudinal observational cohort study, 383 treatment\u2010na\u00efve adults with HIV\u20101 initiating ANV\/lamivudine\/tenofovir disoproxil fumarate (ANV\/3TC\/TDF) were followed for 48 weeks. Virological, immunological, anthropometric, metabolic, hepatic, and renal parameters were assessed repeatedly. Longitudinal changes in continuous outcomes were analyzed using linear mixed models, and repeated virological suppression outcomes were evaluated using generalized estimating equations. Virological suppression increased from 80.42% (308\/383) at Week 24 to 89.56% (343\/383) at Week 48, whereas 10.44% participants (40\/383) were not suppressed at Week 48. Among the Week\u201048 nonsuppressed participants, resistance mutations were uncommon and 36\/40 later achieved HIV\u20101 RNA\u2009&lt;\u200950\u2009copies\/mL on at least two consecutive measurements. CD4+ T\u2010cell counts and CD4\/CD8 ratio improved significantly over time, with an estimated mean CD4+ increase of 246.43\u2009cells\/\u03bcL at Week 48. Body weight and body mass index showed modest early increases followed by lower values at Week 48 relative to baseline. Favorable longitudinal trends were also observed in fasting glucose, lipid parameters, alanine aminotransferase, aspartate aminotransferase, and total bilirubin. In contrast, estimated glomerular filtration rate declined and uric acid levels decreased during follow\u2010up. In this 48\u2010week real\u2010world cohort, ANV\/3TC\/TDF was associated with sustained virological suppression, immune recovery, and generally favorable longitudinal trends in several metabolic and hepatic markers. However, because of the observational single\u2010arm design and the inability to separate the contributions of ANV, the TDF\u2010containing backbone, and recovery from baseline disease status, these findings should be interpreted cautiously and regarded as hypothesis\u2010generating rather than confirmatory.<\/jats:p>","DOI":"10.1002\/jmv.71038","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T10:59:37Z","timestamp":1783162777000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic and Immunological Trajectories and Virological Outcomes of Ainuovirine\u2010Based Antiretroviral Therapy: A 48\u2010Week Longitudinal Cohort Study in Treatment\u2010Na\u00efve Adults"],"prefix":"10.1002","volume":"98","author":[{"given":"Lin","family":"Gan","sequence":"first","affiliation":[{"name":"Department of Infection Guiyang Public Health Clinical Center Guiyang Guizhou 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