{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:44:49Z","timestamp":1785840289371,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Extracorporeal membrane oxygenation (ECMO) is used to manage severe acute respiratory distress syndrome (ARDS) and is associated with immune modulation. Torque teno virus (TTV) has been proposed as a surrogate marker of immune competence, but it remains unclear whether ECMO influences TTV levels. In this exploratory, retrospective, single\u2010center cohort study, TTV DNA was quantified by qPCR in 174 paired bronchoalveolar lavage (BAL) and plasma samples from 50 adults with COVID\u201019\u2010associated ARDS. Plasma samples from 40 healthy blood donors were included as controls for baseline comparison. We compared TTV loads between ECMO and non\u2010ECMO patients, assessed longitudinal trends, examined BAL\u2010plasma correlation, and explored associations with mortality and secondary infections. Early plasma TTV in COVID\u201019 ARDS was lower than in healthy controls (3.20\u2009\u00d7\u200910\n                      <jats:sup>2<\/jats:sup>\n                      vs 6.31\u2009\u00d7\u200910\n                      <jats:sup>1<\/jats:sup>\n                      c\/ml,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041). However, linear regression in log space showed significant growth in BAL and plasma TTV loads over time (R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.1813 and 0.2720 respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Longitudinal BAL and plasma TTV loads were closely correlated (R\u2009=\u20090.8295,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) although BAL TTV loads were consistently higher (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Early BAL and plasma TTV loads did not differ significantly between ECMO and non\u2010ECMO patients and showed poor discrimination for ICU mortality and burden of secondary infections. While TTV load showed compartment\u2010specific and time\u2010dependent kinetics in COVID\u201019\u2010associated ARDS, it was not associated with ECMO status. Early TTV levels did not predict mortality or secondary infections, arguing against its use as a standalone biomarker in this setting.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.71047","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T12:17:01Z","timestamp":1783167421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Torque Teno Virus Dynamics in Plasma and BAL of COVID\u201019 ARDS Patients With and Without ECMO"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7980-7010","authenticated-orcid":false,"given":"Armin Marcus","family":"Bumberger","sequence":"first","affiliation":[{"name":"Department of Medicine I Medical University of Vienna Vienna 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