{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:29:01Z","timestamp":1787671741352,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We compared the effectiveness of tenofovir (TFV)\u2010based triple regimens (TT) to TFV\u2010sparing dual therapies (DT) in virologically suppressed, HBsAg\u2212\/HBcAb+ people living with HIV (PLWH). We emulated a target trial including adults PLWH from five University Hospitals, with HBsAg\u2212\/HBcAb+ serostatus, starting a TT with unsuppressed serum HIV\u2010RNA and reaching HIV\u2010RNA\u2009&lt;\u200950\u2009cp\/mL (baseline). PLWH starting a DT (3TC\u2009+\u2009bPI or DTG, DTG\u2009+\u2009RPV, DOR\u2009+\u2009DTG or long\u2010acting CAB\u2009+\u2009RPV) were considered in the \u201ctreatment\u201d\u2010group only if they switched within a 1\u2010year grace period; all other PLWH were considered \u201ccontrol\u201d\u2010group. To emulate randomization, participants were cloned at baseline and assigned the opposite strategy, then censored at the time of strategy\u2010deviation and assigned a weight based on the inverse\u2010probability of being uncensored. Probabilities of 5\u2010year virological failure (VF; two consecutive HIV\u2010RNA\u2009&gt;\u200950\u2009cp\/mL or a single HIV\u2010RNA\u2009\u2265\u2009200\u2009cp\/mL) were estimated through a weighted Kaplan\u2013Meier estimator. Overall, 415 PLWH were eligible for study analysis: 71 (17.1%) started a DT (3TC\u2010based: 78.9%) during follow\u2010up. They were mainly men (329, 79.3%), with a median age of 48 years. In the weighted analysis, the estimated probabilities of VF were: 29.3% for DT and 29.9% for TT at 5 years (difference: 0.5%; 95% CI: \u221228.7, +21.6). A higher VF risk was seen in the subset of PLWH with undetectable HBsAb at the longest follow\u2010up available (4 years), independently of treatment group: 15.5% and 36.8% with DT and TT, respectively (difference: \u221221.3%; 95% CI: \u221230.3, \u221213.8). Switch to a TFV\u2010sparing DT, compared with continuing a TT, was not associated with an increased risk of VF in PLWH and prior HBV infection.<\/jats:p>","DOI":"10.1002\/jmv.71070","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T19:27:32Z","timestamp":1784662052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk of Virological Failure After Switch to a Tenofovir\u2010Sparing Dual Therapy in Virologically Suppressed People With HIV and Past HBV Infection"],"prefix":"10.1002","volume":"98","author":[{"given":"A.","family":"Borghetti","sequence":"first","affiliation":[{"name":"Infectious Diseases Department, Azienda Ospedaliero\u2010Universitaria Pisana University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Giacomelli","sequence":"additional","affiliation":[{"name":"III Infectious Diseases Unit ASST Fatebenefratelli Sacco, Luigi Sacco Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. F.","family":"Salvo","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1384-7847","authenticated-orcid":false,"given":"A.","family":"Cervo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Azienda Ospedaliero\u2010Universitaria of Modena Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6756-2533","authenticated-orcid":false,"given":"S.","family":"Colombaioni","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Azienda Ospedaliero\u2010Universitaria Pisana University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Lagi","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4623-9976","authenticated-orcid":false,"given":"G.","family":"Baldin","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Mussini","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Azienda Ospedaliero\u2010Universitaria of Modena Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Oreni","sequence":"additional","affiliation":[{"name":"III Infectious Diseases Unit ASST Fatebenefratelli Sacco, Luigi Sacco Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Antinori","sequence":"additional","affiliation":[{"name":"III Infectious Diseases Unit ASST Fatebenefratelli Sacco, Luigi Sacco Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Formica","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Menozzi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Azienda Ospedaliero\u2010Universitaria of Modena Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Di Giambenedetto","sequence":"additional","affiliation":[{"name":"Catholic University of the Sacred Heart Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6587-4794","authenticated-orcid":false,"given":"A.","family":"Gori","sequence":"additional","affiliation":[{"name":"III Infectious Diseases Unit ASST Fatebenefratelli Sacco, Luigi Sacco Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Falcone","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Azienda Ospedaliero\u2010Universitaria Pisana University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization Hepatitis B [Fact Sheet] (2025) https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-b."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70135-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1201796"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283491e3e"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13680"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001574"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001417"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2024.107294"},{"key":"e_1_2_8_10_1","unstructured":"EACS Guidelines Version 12.1 (2024)."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaf039"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000003248"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k182"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyaa057"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000001808"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103020200"},{"key":"e_1_2_8_17_1","unstructured":"J. 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