{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T19:36:45Z","timestamp":1792870605339,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The present study aims to characterize the impact of Epstein\u2010Barr virus (EBV) lytic replication on liver disease in patients with chronic hepatitis B virus (HBV) infection. We retrospectively enrolled 261 patients with HBeAg\u2010negative chronic HBV infection who were admitted to Zhongnan Hospital between 2019 and 2025. Plasma levels of HBV\u2010DNA, EBV\u2010DNA, and liver function parameters were collected. Patients were grouped based on their viral DNA status, and the association between viral DNA status and liver function was evaluated. Compared to the HBV\u2010DNA\u2010negative group, HBV\u2010DNA\u2010positivity was significantly associated with aggravated hepatic injury, as evidenced by elevated ALT, AST, lymphocyte count, and fibrosis scores (APRI and FIB\u20104). Notably, regardless of HBV\u2010DNA status or the stage of liver disease (CHB or LC), EBV\u2010DNA\u2010positivity was consistently associated with significantly lower plasma albumin (Alb) levels and albumin\u2010to\u2010globulin (A\/G) ratio compared to EBV\u2010DNA\u2010negative patients. The reduction in the A\/G ratio was attributable to decreased Alb levels rather than to elevated globulin (Glb) levels. These results suggest that EBV lytic replication was associated with hypoalbuminemia in this study. Circulating EBV\u2010DNA status holds promise as a potential biomarker for monitoring disease progression, or assessing disease severity in patients with chronic HBV infection.<\/jats:p>","DOI":"10.1002\/jmv.71071","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:27:26Z","timestamp":1790688446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between EBV Lytic Replication and Liver Injury in Patients With HBeAg\u2010Negative Chronic HBV Infection"],"prefix":"10.1002","volume":"98","author":[{"given":"Yongxi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Zhongnan Hospital of Wuhan University, Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Zhongnan Hospital of Wuhan University, Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Zhongnan Hospital of Wuhan University, Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Zhongnan Hospital of Wuhan University, Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xien","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Zhongnan Hospital of Wuhan University, Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Lan","sequence":"additional","affiliation":[{"name":"ABSL\u2010III Laboratory at the Center for Animal Experiment Wuhan University Wuhan Hubei China"},{"name":"State Key Laboratory of Virology and Biosafety College of Life Sciences, Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Zhuang","sequence":"additional","affiliation":[{"name":"ABSL\u2010III Laboratory at the Center for Animal Experiment Wuhan University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Global Hepatitis Report 2026","author":"WHO","year":"2026"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/hbsn-2024-754"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology10060483"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.901688"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2022.12.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.02.006"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i33.4130"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-019-1021-1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.03.002"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3488-8"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31865-8"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2021.00443"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.27834"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.12.018"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15311"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-022-02541-1"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26805-8"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13962"},{"issue":"2","key":"e_1_2_9_20_1","article-title":"Epstein\u2010Barr Acute Viral Hepatitis With Hyperferritinemia Presents as Obstructive Cholangitis","volume":"16","author":"Trivedi D.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.14008"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.25597"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00014"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.71071","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.71071","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.71071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T18:54:29Z","timestamp":1792868069000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.71071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/jmv.71071"],"URL":"https:\/\/doi.org\/10.1002\/jmv.71071","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"assertion":[{"value":"2026-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71071"}}