{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:25:47Z","timestamp":1787667947873,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Dengue virus (DENV) remains a major public health concern in Southeast Asia, disproportionately affecting children. In Myanmar, DENV\u20103 Genotype III predominated before 2017, with Genotype I emerging thereafter. To assess the impact of this emergence on antibody responses, we analyzed paired acute and convalescent serum samples from 38 pediatric dengue patients collected between 2017 and 2019 alongside archived 2004 samples. Neutralization and in vitro antibody\u2010dependent enhancement (ADE) were assessed against DENV\u20103 Genotypes I and III and other serotypes, with cross\u2010reactivity analysis to Zika and Japanese encephalitis viruses. Samples from 2004 showed reduced neutralization and higher ADE for Genotype I, consistent with its absence at the time. In contrast, 2017\u20132019 samples exhibited comparable neutralization for both genotypes, with genotype\u2010 and year\u2010dependent ADE differences, indicating that Genotype I emergence was associated with evolving functional antibody profiles. Hence, providing immunological evidence for continued co\u2010circulation of DENV\u20103 Genotypes I and III in Myanmar. Future prospective pediatric cohort studies with continuous surveillance of circulating orthoflaviviruses and their genotypes, are essential to elucidate how pre\u2010existing dengue immunity shapes genotype emergence and cross\u2010orthoflavivirus immunity in endemic regions.<\/jats:p>","DOI":"10.1002\/jmv.71079","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T07:45:00Z","timestamp":1785138300000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antibody Responses in Pediatric Dengue Indicate Emergence and Co\u2010Circulation of DENV\u20103 Genotypes I and III in Myanmar and Orthoflavivirus Cross\u2010Reactivity"],"prefix":"10.1002","volume":"98","author":[{"given":"Jean Claude","family":"Balingit","sequence":"first","affiliation":[{"name":"Department of Tropical Viral Vaccine Development Institute of Tropical Medicine, Nagasaki University, Nagasaki City Nagasaki 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