{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:25:44Z","timestamp":1787667944145,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Herpes zoster (HZ), caused by varicella\u2013zoster virus reactivation, is characterized by painful dermatomal eruptions. Systemic metabolic alterations during acute infection remain incompletely defined. In this exploratory case\u2013control study, serum samples from 47 acute HZ patients and 30 healthy controls were analyzed using untargeted ultra\u2010high\u2010performance liquid chromatography\u2013high\u2010resolution mass spectrometry. Differential metabolic features were identified using models adjusted for age and analytical batch (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05; FC\u2009\u2265\u20091.2 or \u2264\u20090.83). Pathway enrichment was explored by over\u2010representation analysis. A nested cross\u2010validated LASSO\u2010logistic regression model incorporating selected metabolites, age, and batch was constructed to assess exploratory internal discrimination. Thirty\u2010eight differential metabolic features were identified, involving nucleoside, amino acid, lipid, and energy metabolism. Pyrimidine\u2010related and amino acid\u2010related pathways appeared among the leading nominal pathways. A four\u2010metabolite panel (Uridine\/Pseudouridine, Uracil, 2\u2010Pyrrolidinone, and\n                      <jats:sub>L<\/jats:sub>\n                      \u2010Methionine), combined with age and batch, yielded an internal cross\u2010validated AUC of 0.91 (\n                      <jats:italic>95% CI<\/jats:italic>\n                      : 0.8369\u20130.9688). These four core metabolic features retained the same directions of change in the age\u2010overlap sensitivity cohort, with nucleoside\u2010related features elevated and\n                      <jats:sub>L<\/jats:sub>\n                      \u2010Methionine decreased in HZ patients. Acute HZ is associated with alterations in serum metabolic features, particularly involving nucleoside\u2010related and amino acid\u2010related signals. These exploratory findings provide a metabolic overview of acute HZ and require validation in independent, age\u2010matched cohorts.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.71087","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T07:44:58Z","timestamp":1785311098000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Metabolic Profiling of Patients With Acute Herpes Zoster"],"prefix":"10.1002","volume":"98","author":[{"given":"Jiahui","family":"Han","sequence":"first","affiliation":[{"name":"Department of Dermatology, China\u2010Japan Friendship Hospital China\u2010Japan Friendship Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing China"},{"name":"Department of Dermatology China\u2010Japan Friendship Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yameng","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Jingmei Group General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6022-3359","authenticated-orcid":false,"given":"Yujun","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology China\u2010Japan Friendship Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhancai","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology China\u2010Japan Friendship Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Dermatology China\u2010Japan Friendship Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6314-3610","authenticated-orcid":false,"given":"Yong","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Dermatology China\u2010Japan Friendship Hospital Beijing China"},{"name":"NHC Key Laboratory of Clinical Big Data Standardization &amp; Integration Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"issue":"3","key":"e_1_2_11_2_1","first-page":"19","article-title":"Herpes Zoster","volume":"169","author":"Schmader K.","year":"2018","journal-title":"Annals of Internal Medicine"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(10)70003-2"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14020192"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2023.2228169"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijdvl.IJDVL_1021_16"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.4c00340"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.721556"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.1009677"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-42363-z"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41387-021-00164-1"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2025.05.016"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.599087"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021521"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228623"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084260"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2021.12.011"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-025-01985-x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117443"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2025.2477647"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12111026"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(78)90068-0"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/bms.1200060106"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00394"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.71087","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.71087","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.71087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:41:32Z","timestamp":1787665292000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.71087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,29]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/jmv.71087"],"URL":"https:\/\/doi.org\/10.1002\/jmv.71087","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,29]]},"assertion":[{"value":"2026-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71087"}}