{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:23:28Z","timestamp":1787657008726,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071633"],"award-info":[{"award-number":["82071633"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Mumps virus (MuV) infection may lead to male infertility. However, the pathological mechanisms of testicular dysfunctions are largely unknown. This study aims to the mechanisms by which MuV infection induces testicular dysfunctions in mice. Intraperitoneal injection of MuV induced up\u2010regulation of cytokines and chemokines including tumor necrosis factor alpha (TNF\u2010\u03b1), monocyte tractant\u20101, IP\u201010. Moreover, MuV infection induced male germ cell apoptosis and impaired spermatogenesis. Notably, MuV injection did not evidently induce dysfunction in Toll\u2010like receptor 2 knockout (TLR2\n                    <jats:sup>\u2010\/\u2010<\/jats:sup>\n                    ) or TNF\u2010\u03b1\n                    <jats:sup>\u2010\/\u2010<\/jats:sup>\n                    mice. MuV did not induce TNF\u2010\u03b1 production in TLR2\n                    <jats:sup>\u2010\/\u2010<\/jats:sup>\n                    mice. The results suggest that MuV induces TNF\u2010\u03b1 production through TLR2, and TNF\u2010\u03b1 leads to testicular dysfunction. Data of this study provide novel insights into the mechanisms underlying MuV\u2010induced testicular dysfunction in mice.\n                  <\/jats:p>","DOI":"10.1002\/jmv.71091","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T07:31:58Z","timestamp":1786433518000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mumps Virus\u2010Induced TNF\u2010\u03b1 Production Through Toll\u2010Like Receptor 2 Mediates Testicular Dysfunction in Male Mice"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2532-5824","authenticated-orcid":false,"given":"Lili","family":"Shi","sequence":"first","affiliation":[{"name":"Institute of Basic Medical Sciences &amp; School of Basic Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Basic Medical Sciences &amp; School of Basic Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Jiang","sequence":"additional","affiliation":[{"name":"Institute of Basic Medical Sciences &amp; School of Basic Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Basic Medical Sciences &amp; School of Basic Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Basic Medical Sciences &amp; School of Basic Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daishu","family":"Han","sequence":"additional","affiliation":[{"name":"Institute of Basic Medical Sciences &amp; School of Basic Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2014.08.013"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3947\/ic.2015.47.1.1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2207595120"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4445"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2008.00837.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.10982"},{"issue":"15","key":"e_1_2_10_8_1","first-page":"606","article-title":"[Infertility After Mumps Orchitis (Author's Transl)]","volume":"123","author":"Bertschat F. 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