{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:18:56Z","timestamp":1787660336484,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Dengue virus (DENV) infection has emerged as a critical global public health challenge, particularly in tropical and subtropical regions, where it continues to cause high morbidity rates and severe disease risks. Given the current lack of specific antiviral therapies in clinical practice, the development of novel anti\u2010DENV agents represents an urgent medical need. In this study, the antiviral activity of a novel compound, TXD\u2010174, was systematically evaluated. It was found that TXD\u2010174 exhibited significant inhibitory effects against DENV2 in vitro. Notably, viral replication was effectively blocked by TXD\u2010174, while cytotoxicity assessments revealed a favorable therapeutic window. Furthermore, the compound demonstrated inhibitory activity against all four DENV serotypes, highlighting its potential as a broad\u2010spectrum anti\u2010dengue agent. Meanwhile, RNA\u2010seq analysis indicated that level of\n                    <jats:italic>IL\u201024<\/jats:italic>\n                    was significantly upregulated. Knockdown of\n                    <jats:italic>IL\u201024<\/jats:italic>\n                    gene reduced the antiviral effect of TXD\u2010174, while overexpression of\n                    <jats:italic>IL\u201024<\/jats:italic>\n                    gene also exhibited good antiviral effects. In virus\u2010infected AG\u2010129 models, TXD\u2010174 was also found to have good in vivo antiviral effects. These findings establish a foundation for further exploration of targeted therapeutic strategies against DENV infections.\n                  <\/jats:p>","DOI":"10.1002\/jmv.71093","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T08:05:31Z","timestamp":1786003531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potent Inhibition of Dengue Virus Infection by Synthetic Compound TXD\u2010174 Through Specific Targeting of IL\u201024"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4071-6078","authenticated-orcid":false,"given":"Jiajia","family":"Han","sequence":"first","affiliation":[{"name":"State Key Laboratory of Muti\u2010organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences Southern Medical University Guangzhou 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