{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:23:59Z","timestamp":1787657039965,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Adenovirus may cause life\u2010threatening infections. While outcomes in immunocompromised patients are well documented, data on critically ill, immunocompetent adults remain limited. To describe the clinical characteristics and outcomes of adenovirus infection in adult intensive care unit (ICU) patients and to identify factors associated with 30\u2010day mortality. This retrospective observational study included adult patients (\u2265\u200916 years) admitted to ICUs between January 2020 and May 2025 with PCR\u2010confirmed adenovirus infection and compatible clinical syndromes, with a primary focus on describing patient characteristics rather than analyzing virological features of the infection. Data were collected from 24 centers in 11 countries. Demographics, comorbidities, clinical characteristics, laboratory findings, treatments, and outcomes were recorded. The primary outcome was 30\u2010day all\u2010cause in\u2010hospital mortality. Variables associated with mortality in univariate analyses were entered into a stepwise multivariable logistic regression model. A total of 126 patients were included; 40 (31.7%) died within 30 days of PCR positivity. The mean age of the entire cohort of patients was 44.9 \u00b1\u200920.4 years (median 48; 16\u201395), and 38.9% were female. Pneumonia was the most common presentation (108\/126, 85.7%), followed by upper respiratory tract infection (18.3%), gastroenteritis (6.3%), conjunctivitis (4.8%), meningoencephalitis (2.4%), and cystitis (1.6%). Significant immunosuppression was present in 29.4%. In multivariable analysis, independent predictors of 30\u2010day mortality included mean arterial pressure \u2264\u200965\u2009mmHg, SOFA score \u2265\u20095, increasing Charlson Comorbidity Index, central venous catheter placement, platelet count &lt;50,000\/\u00b5L (borderline significance), procalcitonin \u2265\u20090.1\u2009ng\/mL, and significant immunosuppression. The final model had 84.9% accuracy, 72.5% sensitivity, and 90.7% specificity. A high percentage of ICU patients with PCR\u2010confirmed adenovirus infection died within 30 days. Hemodynamic instability, organ failure severity, comorbidity burden, inflammatory response, thrombocytopenia, and immunosuppression are key determinants of poor outcome.<\/jats:p>","DOI":"10.1002\/jmv.71095","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T09:44:59Z","timestamp":1786355099000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characteristics of Critically ill Adult Patients Infected With Adenovirus: An International ID\u2010IRI Study"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2793-8685","authenticated-orcid":false,"given":"Refika Nur","family":"Kahraman","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Gulhane Training and Research Hospital University of Health Sciences Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6265-5227","authenticated-orcid":false,"given":"Hakan","family":"Erdem","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Gulhane Training and Research Hospital University of Health Sciences Ankara T\u00fcrkiye"},{"name":"ID\u2010IRI Lead Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3613-0523","authenticated-orcid":false,"given":"Handan","family":"Ankarali","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics, Faculty of Medicine Hospital Istanbul Medeniyet University Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9983-0308","authenticated-orcid":false,"given":"Yasemin","family":"Cag","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Goztepe Prof. Dr. Suleyman Yalcin City Hospital Istanbul Medeniyet University Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2860-1794","authenticated-orcid":false,"given":"Esra","family":"Kocoglu","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine Hospital Istanbul Medeniyet University Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Amer","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, Zagazig Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nor Hayati","family":"Shaharuddin","sequence":"additional","affiliation":[{"name":"Hospital Pantai Ayer Keroh Melaka Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine Kubra","family":"Dindar","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Siirt Training and Research Hospital Siirt T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9385-6542","authenticated-orcid":false,"given":"Behiye Deniz","family":"Kosoval\u0131","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, Ankara City Hospital University of Health Sciences Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1461-5933","authenticated-orcid":false,"given":"Firdevs Tugba","family":"Bozkurt\u2010Bicer","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, Ankara City Hospital University of Health Sciences Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5120-4877","authenticated-orcid":false,"given":"Hasip","family":"Kahraman","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Eski\u015fehir Osmangazi University Eski\u015fehir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6898-7516","authenticated-orcid":false,"given":"Nida","family":"Ozcan","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine Dicle University Diyarbak\u0131r T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Pshenichnaya","sequence":"additional","affiliation":[{"name":"Central Research Institute of Epidemiology Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feyza","family":"Gokcuk","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Ege University Izmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2211-0855","authenticated-orcid":false,"given":"Sumeyra","family":"Kayali","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology F\u0131rat University Faculty of Medicine Elaz\u0131\u011f T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4689-720X","authenticated-orcid":false,"given":"Meltem","family":"Tasbakan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Ege University Izmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hulya","family":"Caskurlu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Goztepe Prof. Dr. Suleyman Yalcin City Hospital Istanbul Medeniyet University Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve","family":"Bozk\u0131r\u2010Uludag","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Goztepe Prof. Dr. Suleyman Yalcin City Hospital Istanbul Medeniyet University Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5008-0139","authenticated-orcid":false,"given":"Merve","family":"Mert\u2010Vahabi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Ege University Izmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilara","family":"Yaman","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Ege University Izmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2560-3265","authenticated-orcid":false,"given":"Ayhan","family":"Akbulut","sequence":"additional","affiliation":[{"name":"Department of Infection Diseases and Clinical Microbiology F\u0131rat University Faculty of Medicine Elaz\u0131\u011f T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sholpan","family":"Kulzhanova","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Astana Medical University Astana Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Cernat","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Clinical Hospital for Infectious Diseases Constanta Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amani","family":"El\u2010Kholy","sequence":"additional","affiliation":[{"name":"Department of Clinical and Chemical Pathology, Faculty of Medicine Cairo University Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0997-1439","authenticated-orcid":false,"given":"Gergana","family":"Lengerova","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology Medical University Plovdiv Bulgaria"},{"name":"Laboratory of Microbiology University Hospital St. George Plovdiv Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"L\u00ed\u0161kov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Faculty Hospital Nitra St. Elisabeth University of Health Care and Social Work Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1047-7457","authenticated-orcid":false,"given":"Haitham Noaman","family":"Eyada","sequence":"additional","affiliation":[{"name":"University of Anbar College of Medicine Department Al\u2010Yarmouk Teaching Hospital Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9316-771X","authenticated-orcid":false,"given":"Mehmet","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, School of Medicine Necmettin Erbakan University Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2877-8128","authenticated-orcid":false,"given":"Abdullah Umut","family":"Pekok","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, VM Medical Park Pendik Hospital Istanbul Ayd\u0131n University Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6630-5742","authenticated-orcid":false,"given":"Bilal Ahmad","family":"Rahimi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Kandahar University Kandahar Afghanistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulden","family":"Yilmaz\u2010Tehli","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Gulhane Training and Research Hospital University of Health Sciences Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cemal","family":"Bulut","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Gulhane Training and Research Hospital University of Health Sciences Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laman","family":"Galimova","sequence":"additional","affiliation":[{"name":"Baku Health Centre Baku Azerbaijan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7339-0869","authenticated-orcid":false,"given":"Serkan","family":"Oncu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Adnan Menderes University Ayd\u0131n T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0436-4122","authenticated-orcid":false,"given":"Merve","family":"Sefa\u2010Sayar","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology University of Health Sciences, Bursa Y\u00fcksek Ihtisas Training and Research Hospital Bursa T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghaydaa","family":"Shehata","sequence":"additional","affiliation":[{"name":"Department of Neurology Assiut University Faculty of Medicine Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Miftode","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Faculty of Medicine Grigore T. Popa University of Medicine and Pharmacy Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0676-6210","authenticated-orcid":false,"given":"Jordi","family":"Rello","sequence":"additional","affiliation":[{"name":"Clinical Research &amp; Innovation in Pneumonia and Sepsis Vall d'Hebron Institute of Research Barcelona Spain"},{"name":"Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES) Instituto de Salud Carlos III Madrid Spain"},{"name":"UR\u2010UM 103 IMAGINER, University Montpellier, Division of Anesthesia Critical Care, Pain and Emergency Medicine, N\u00eemes University Hospital N\u00eemes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1879","volume-title":"Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases","author":"Stephenson K. E.","year":"2026"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-024-02361-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir040"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0011151"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-99608-y"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.866494"},{"key":"e_1_2_9_8_1","first-page":"1181","article-title":"Acute Respiratory Disease Associated with Adenovirus Serotype 14\u2014four States, 2006\u20132007","volume":"56","author":"Centers for Disease Control and Prevention (CDC)","year":"2007","journal-title":"MMWR. Morbidity and Mortality Weekly Report"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/598521"},{"key":"e_1_2_9_10_1","first-page":"836","volume-title":"Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases","author":"Daly J. S.","year":"2026"},{"key":"e_1_2_9_11_1","first-page":"1264","volume-title":"Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases","author":"LaRocque R. C.","year":"2026"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/425368"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag-0908-158"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.12.004"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.14.1754"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1751-0473-3-17"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115101"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005337"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-023-02742-8"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy820"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/172.3.629"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03479.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13071670"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2009.00452.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703798"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.09.007"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix317"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.es2014.19.39.20914"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00358-25"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.71095","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.71095","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.71095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:11:51Z","timestamp":1787656311000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.71095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/jmv.71095"],"URL":"https:\/\/doi.org\/10.1002\/jmv.71095","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71095"}}