{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:23:55Z","timestamp":1787657035470,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Nasopharyngeal carcinoma (NPC) is a type of cancer that is prevalent in southern China. In the development of NPC, the oncogenic protein LMP1, which is encoded by EBV, plays a very important role. The Wnt pathway is abnormally activated in many types of malignant tumors. The interaction between AXIN and DVL2 is pivotal for the breakdown of the \u03b2\u2010catenin destruction complex and Wnt\/\u03b2\u2010catenin pathway activation. However, the molecular mechanisms underlying this process in NPC are not well understood. In this study, we identified the transmembrane protein LMP1 as an interacting partner of DVL2, which positively regulates the Wnt\/\u03b2\u2010catenin pathway by inhibiting the AXIN\u2010DVL2 interaction. LMP1 overexpression enhanced NPC cell growth, metastasis, and stemness, whereas LMP1 knockdown suppressed these abilities. Our findings reveal new oncogenic roles for LMP1 in NPC progression.<\/jats:p>","DOI":"10.1002\/jmv.71098","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T08:00:00Z","timestamp":1786003200000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LMP1 Activates the Wnt\/\u03b2\u2010Catenin Signaling Pathway and Promotes Nasopharyngeal Carcinoma Progression Through Its Interaction With DVL2"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4186-537X","authenticated-orcid":false,"given":"Liyu","family":"Liu","sequence":"first","affiliation":[{"name":"Xiangya Cancer Center, Xiangya Hospital, Central South University Changsha China"},{"name":"Key Laboratory of Molecular Radiation Oncology Hunan Province Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Changsha China"},{"name":"Hunan International Science and Technology Collaboration Base of Precision Medicine for Cancer Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0558-5250","authenticated-orcid":false,"given":"Lunquan","family":"Sun","sequence":"additional","affiliation":[{"name":"Xiangya Cancer Center, Xiangya Hospital, Central South University Changsha China"},{"name":"Key Laboratory of Molecular Radiation Oncology Hunan Province Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Changsha China"},{"name":"Hunan International Science and Technology Collaboration Base of Precision Medicine for Cancer Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"He","sequence":"additional","affiliation":[{"name":"Xiangya Cancer Center, Xiangya Hospital, Central South University Changsha China"},{"name":"Key Laboratory of Molecular Radiation Oncology Hunan Province Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Changsha China"},{"name":"Hunan International Science and Technology Collaboration Base of Precision Medicine for Cancer Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7166-9874","authenticated-orcid":false,"given":"Zhi","family":"Li","sequence":"additional","affiliation":[{"name":"Xiangya Cancer Center, Xiangya Hospital, Central South University Changsha China"},{"name":"Key Laboratory of Molecular Radiation Oncology Hunan Province Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Changsha China"},{"name":"Hunan International Science and Technology Collaboration Base of Precision Medicine for Cancer Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30956-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.640207"},{"issue":"9","key":"e_1_2_10_4_1","first-page":"2064","article-title":"Comparison Between Nedaplatin and Cisplatin Plus Docetaxel Combined with Intensity\u2010Modulated Radiotherapy for Locoregionally Advanced Nasopharyngeal Carcinoma: A Multicenter Randomized Phase II Clinical Trial","volume":"6","author":"Tang C.","year":"2016","journal-title":"American Journal of Cancer Research"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01928-2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-024-10176-9"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.01.014"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13215451"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.06.021"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44455-w"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1164-y"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2023.01.030"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-023-05099-7"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-024-01563-4"},{"issue":"14","key":"e_1_2_10_15_1","first-page":"44","article-title":"Nejak\u2010Bowen. 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