{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:22:11Z","timestamp":1787656931068,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:00:00Z","timestamp":1786752000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      This study aimed to compare the prognostic performances of individual laboratory parameters and biomarker ratios derived from them formortality in patients with Crimean\u2010Congo Hemorrhagic Fever (CCHF), and to examine the temporal stability of the strongest index. A total of 1171 adult patients with laboratory\u2010confirmed CCHF followed between 2014 and 2024 were retrospectively included in the study. Admission data were recorded, and the mortality discriminative performances of individual and derived biomarkers (interleukin\u20106\u2010to\u2010platelet ratio [IL\u20106\/PLT], interleukin\u20106\u2010to\u2010calcium ratio [IL\u20106\/Ca], ferritin\u2010to\u2010platelet ratio [Ferritin\/PLT], and ferritin\u2010to\u2010calcium ratio [Ferritin\/Ca]) for mortality were compared using ROC analysis. Ninety\u2010seven patients (8.3%) resulted in mortality. Among the individual parameters, IL\u20106 demonstrated the highest discriminative ability for mortality (AUC: 0.887). Among the derived indices, the IL\u20106\/PLT ratio demonstrated the highest overall performance with an AUC value of 0.920 (95% CI: 0.871\u20130.969;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The optimal cut\u2010off value for the IL\u20106\/PLT ratio was determined as 0.78 (88% sensitivity, 81% specificity). Mortality reached 100% in all patients with a ratio of \u2265\u200916. Sequential ROC analyzes demonstrated that the IL\u20106\/PLT ratio maintained high prognostic stability throughout the course of infection. The IL\u20106\/PLT ratio, a combined indicator of inflammatory response and hemostatic dysfunction, is a powerful biomarker candidate for the early and dynamic monitoring of mortality risk in CCHF.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.71104","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T10:32:41Z","timestamp":1786789961000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic Prognostic Value of IL\u20106\/PLT Ratio for Mortality Discrimination in Patients With Crimean\u2010Congo Hemorrhagic Fever: Sequential ROC Analysis Throughout the Clinical Course"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3415-5927","authenticated-orcid":false,"given":"Murtaza","family":"\u00d6z","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3944-4608","authenticated-orcid":false,"given":"Caner","family":"\u00d6ks\u00fcz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8447-7695","authenticated-orcid":false,"given":"Ertu\u011frul","family":"Keskin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcveyda","family":"Parlak","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra \u0130rem","family":"Da\u011fci","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c7i\u011fdem","family":"Tutku Ba\u011f","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6358-248X","authenticated-orcid":false,"given":"R\u0131dvan","family":"Karaarslan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8738-0760","authenticated-orcid":false,"given":"Halef Okan","family":"Do\u011fan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Sivas Cumhuriyet University School of Medicine Sivas T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6518-7361","authenticated-orcid":false,"given":"Seyit Ali","family":"B\u00fcy\u00fcktuna","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9515-770X","authenticated-orcid":false,"given":"Nazif","family":"Elaldi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2025.107917"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2025.116724"},{"key":"e_1_2_10_4_1","unstructured":"World Health Organization.Crimean\u2010Congo Haemorrhagic Fever 2026 https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/crimean-congo-haemorrhagic-fever."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-014-2238-0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.14744\/ijmb.2025.60590"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed10100287"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000330"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid3005.231646"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109130"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2015.12.006"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2022.0007"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/20477724.2026.2618468"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1615947"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5049.144643"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31828cf436"}],"container-title":["Journal 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CCHF"],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/jmv.71104"],"URL":"https:\/\/doi.org\/10.1002\/jmv.71104","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71104"}}