{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:21:15Z","timestamp":1787656875744,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Immune reconstitution (IR) after allogeneic hematopoietic stem cell transplantation (HSCT) is crucial to prevent transplant\u2010related complications. Plasma viral load of Torque teno virus (TTV\u2010VL), considered apathogenic and the main component of human virome, may reflect immunosuppression state. In this single\u2010center prospective study we recruited 32 children undergoing HSCT to explore the potential role of TTV\u2010VL as an IR marker and predictor of clinical outcome. Blood samples were obtained prior to stem cell infusion, on the day of transplantation, and on days +15, +30, +90, +180, +270, and +360 post\u2010transplant. TTV\u2010VL diminished after conditioning, increased after engraftment, and correlated with lymphopenia since day +30, consistent with previous reports. In exploratory analyses, correlations with clinical outcomes were limited by small sample size: higher TTV\u2010VL at day +15 correlated with accumulated bacterial infection episodes and mortality at 1 year; at pre\u2010HSCT and at +180 days TTV\u2010VL predicted viral reactivations at the subsequent study timepoint; at +30, TTV\u2010VL anticipated graft versus host disease. Associations with NK cell function and HLA\/KIR variables were also observed, although no mechanistic inference could be drawn. Overall, these results are hypothesis\u2010generating and warrant validation in larger studies.<\/jats:p>","DOI":"10.1002\/jmv.71113","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:33:11Z","timestamp":1787311991000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Torque Teno Virus (TTV) Viremia as a Biomarker of Immune Reconstitution and Outcomes in Pediatric Allogeneic Hematopoietic Stem Cell Transplantation"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5666-1911","authenticated-orcid":false,"given":"Yasmina","family":"Mozo","sequence":"first","affiliation":[{"name":"Pediatric Hemato\u2010Oncology Department La Paz University Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Del Rosal","sequence":"additional","affiliation":[{"name":"General Pediatrics and Infectious Diseases Department La Paz University Hospital Madrid Spain"},{"name":"Hospital La Paz Institute for Health Research (IdiPAZ) Madrid Spain"},{"name":"Center for Biomedical Network Research on Rare Diseases (CIBERER U767) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iker","family":"Falces\u2010Romero","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Parasitology Department La Paz University Hospital Madrid Spain"},{"name":"Center for Biomedical Network Research on Infectious Diseases (CIBERINFEC) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karima","family":"Al\u2010Akioui Sanz","sequence":"additional","affiliation":[{"name":"CIBERER\u2010ISCIII, IdiPAZ\u2010CNIO Translational Research Unit in Pediatric Hemato\u2010Oncology La Paz University Hospital Research Institute, Spanish National Cancer Center Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Atucha","sequence":"additional","affiliation":[{"name":"Hospital La Paz Institute for Health Research (IdiPAZ) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0589-4873","authenticated-orcid":false,"given":"Lidia","family":"Perti\u00f1ez","sequence":"additional","affiliation":[{"name":"CIBERER\u2010ISCIII, IdiPAZ\u2010CNIO Translational Research Unit in Pediatric Hemato\u2010Oncology La Paz University Hospital Research Institute, Spanish National Cancer Center Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itsaso","family":"Losantos","sequence":"additional","affiliation":[{"name":"Statistics Department La Paz University Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Moreno Hidalgo","sequence":"additional","affiliation":[{"name":"Histocompatibility. 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