{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:20:50Z","timestamp":1787656850298,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Donor Epstein\u2010Barr virus (EBV)\u2010seropositive (D\u2009+\u2009) serostatus is a risk factor for post\u2010transplant lymphoproliferative disorder (PTLD) in EBV\u2010seronegative recipients. The impact of donor EBV serostatus on mortality and PTLD in EBV\u2010seropositive (R\u2009+\u2009) thoracic organ transplant recipients is unknown. We analyzed 49\u2009458 EBV R+ thoracic transplant recipients from the Organ Procurement and Transplantation Network (2004\u20132021). The primary exposure was EBV D+ serostatus; outcomes were death and PTLD. Associations were assessed using multivariable Cox and logistic regression models. EBV D+ serostatus was not associated with mortality but significantly reduced the hazard of PTLD in lung and heart\u2010lung (L\/HLT) recipients (adjusted hazard ratio, 0.59; 95% CI: 0.42\u20130.83). No association was observed in heart transplants. Notably, 48.7% of PTLD cases in EBV R\u2009+\u2009L\/HLT occurred early after transplant when the donor was EBV\u2010seronegative (D\u2010). In an exploratory subgroup analysis of PTLD cases, EBV D+ serostatus was associated with lower odds of early vs late PTLD (adjusted odds ratio [aOR]: 0.40; 95% CI: 0.22\u20130.73). Conversely, L\/HLT had twice the odds of early PTLD (aOR: 2.62; 95% CI: 1.68 \u2013 4.08). EBV D\u2010\/R\u2009+\u2009L\/HLT recipients carry a substantially higher risk of PTLD than EBV D\u2009+\u2009\/R+ recipients, driven predominantly by early\u2010onset disease.<\/jats:p>","DOI":"10.1002\/jmv.71117","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:28:10Z","timestamp":1787567290000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Epstein\u2010Barr Virus Donor Serostatus on Post\u2010Transplant Mortality and Post\u2010Transplant Lymphoproliferative Disorder in Epstein\u2010Barr Virus Seropositive Thoracic Organ Transplant Recipients: Data from the Organ Procurement and Transplantation Network"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9304-2114","authenticated-orcid":false,"given":"Khuloud","family":"Aldhaheri","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, College of Medicine and Health Sciences United Arab Emirates University Al Ain United Arab Emirates"},{"name":"Department of Medicine, Division of Infectious Disease University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4173-5858","authenticated-orcid":false,"given":"Robert C.","family":"Wright","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences University of British Columbia Vancouver British Columbia Canada"},{"name":"BC Children's Hospital Research Institute Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6253-293X","authenticated-orcid":false,"given":"Stephen","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases University of Saskatchewan Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1215-6005","authenticated-orcid":false,"given":"Mohsin","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Infectious Diseases, Hospital for Sick Children Toronto Ontario Canada"},{"name":"Department of Pediatrics London Health Sciences Centre, Division of Infectious Diseases London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3772-2202","authenticated-orcid":false,"given":"Brian","family":"Clarke","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2585-5411","authenticated-orcid":false,"given":"C\u00e9line","family":"Bergeron","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Respiratory Medicine University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0158-2324","authenticated-orcid":false,"given":"Allison","family":"Mah","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Disease University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alissa","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Disease University of British Columbia Vancouver British Columbia 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