{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:39:03Z","timestamp":1792618743273,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Hepatitis B virus\u2010related acute\u2010on\u2010chronic liver failure (HBV\u2010ACLF) is associated with a high short\u2010term mortality rate. Therefore, early and accurate prognostic prediction is crucial for precise clinical management. This study aims to investigate the expression patterns of intercellular adhesion molecule\u20101 (ICAM\u20101) and its predictive value for the short\u2010term prognosis of patients with HBV\u2010ACLF. The Methylight method was used to quantitatively detect ICAM\u20101 promoter methylation level in peripheral blood mononuclear cells (PMBCs) of 286 participants. Meanwhile, the mRNA and plasma expression levels of ICAM\u20101 were determined using RT\u2010qPCR and ELISA, respectively. The ICAM\u20101 promoter methylation levels in PBMCs of HBV\u2010ACLF patients were significantly lower than those in chronic hepatitis B (CHB) patients and healthy controls (HCs), whereas the mRNA and plasma expression levels of ICAM\u20101 were markedly elevated. The ICAM\u20101 methylation levels in HBV\u2010ACLF patients correlated with specific clinical parameters. Among HBV\u2010ACLF patients, ICAM\u20101 methylation levels were significantly lower in the non\u2010survivor groups at both 28 and 90 days. The study further revealed that ICAM\u20101 methylation level serves as an independent influencing factor for the prognosis of HBV\u2010ACLF patients at 28 and 90 days. Based on ROC curve and Kaplan\u2013Meier curves, ICAM\u20101 methylation levels demonstrated excellent performance in predicting 28\u2010 and 90\u2010day mortality in patients with HBV\u2010ACLF. In conclusion, patients with HBV\u2010ACLF exhibit hypomethylation of the ICAM\u20101 promoter. The combination of ICAM\u20101 promoter methylation level and MELD score can effectively enhance the predictive ability for the short\u2010term prognosis of HBV\u2010ACLF patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.71118","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:50:32Z","timestamp":1788519032000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ICAM\u20101 Hypomethylation Predicts Poor Prognosis in Patients With Hepatitis B Virus\u2010Related Acute\u2010on\u2010Chronic Liver Failure"],"prefix":"10.1002","volume":"98","author":[{"given":"Miao\u2010Miao","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Hepatology Qilu Hospital of Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Xin","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Hepatology Qilu Hospital of Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Serve Liver Disease Shandong Public Health Clinical Center of Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The First Affiliated Hospital of Shandong First Medical University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe\u2010Zhe","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Hepatology Qilu Hospital of Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Chen","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Hepatology Qilu Hospital of Shandong University Jinan Shandong China"},{"name":"Hepatology Institute of Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6297-0147","authenticated-orcid":false,"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatology Qilu Hospital of Shandong University Jinan Shandong China"},{"name":"Hepatology Institute of Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0103"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322161"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.583423"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314641"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2025.2500490"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-06472-1"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01709751"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.06.012"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.05.026"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.111.6.3129"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707406104"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology12050743"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.2MR0220-549R"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202400295"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-025-07515-x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4716"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v7.i1.120"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840120123"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.23.11441"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep32341"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2021.100303"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac664"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-023-01550-5"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3724\/abbs.2024237"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-019-09946-3"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29800"},{"key":"e_1_2_12_28_1","first-page":"1425","article-title":"Guidelines for the Prevention and Treatment of Chronic Hepatitis B (Version 2022)","volume":"11","author":"You H.","year":"2023","journal-title":"Journal of Clinical and Translational Hepatology"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2020.100176"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-330584"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/he.2000.5852"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2023.03.006"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2025-335651"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27795"},{"key":"e_1_2_12_35_1","first-page":"96","article-title":"Acute\u2010on\u2010Chronic Liver Failure","volume":"122","author":"Trebicka J.","year":"2025","journal-title":"Deutsches Arzteblatt International"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1694659"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-333308"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2024.2404953"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1515\/jtim-2025-0014"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46047-8"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-022-00891-w"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(00)00223-9"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.106"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2023.117487"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-022-08726-x"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.96882"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1994.tb06019.x"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2025.2595332"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.112"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8090953"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2024.5379"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-016-0218-1"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2024.1421597"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/3.1.83"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2021.10.007"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.71118","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.71118","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.71118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:57:17Z","timestamp":1792616237000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.71118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":54,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/jmv.71118"],"URL":"https:\/\/doi.org\/10.1002\/jmv.71118","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71118"}}