{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:08:36Z","timestamp":1790086116192,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272396"],"award-info":[{"award-number":["82272396"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hepatitis E virus (HEV) is a significant cause of acute liver failure (ALF). The role of glycogen phosphorylase L (PYGL) in the diagnosis and prognosis of HEV\u2010ALF remains unclear. This study collected clinical data and baseline characteristics from HEV\u2010ALF patients, acute hepatitis E (AHE) patients, and healthy controls (HCs), measuring serum PYGL levels in each group. Methods including Orthogonal partial least squares discriminant analysis (OPLS\u2010DA), receiver operating characteristic (ROC) and decision curve analysis (DCA) were used to evaluate the clinical utility of PYGL. Results showed that PYGL effectively diagnosed HEV\u2010ALF (AUC\u2009=\u20090.911). PYGL levels were significantly higher in HEV\u2010ALF patients than in AHE patients and HCs (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Among HEV\u2010ALF patients, non\u2010survivors exhibited higher PYGL levels than survivors (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). PYGL demonstrated good predictive ability for 30\u2010day mortality (AUC\u2009=\u20090.859). OPLS\u2010DA and DCA confirmed its strong decision\u2010making utility. Furthermore, PYGL levels escalated with increasing organ failure and paralleled clinical worsening, being highest in the deterioration group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). PYGL is a potential diagnostic and prognostic biomarker in HEV\u2010ALF patients, where elevated levels indicate poorer outcomes and support early intervention.\n                  <\/jats:p>","DOI":"10.1002\/jmv.71126","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:06:21Z","timestamp":1788339981000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["PYGL as a Novel Biomarker for Disease Progression and Prognosis in HEV\u2010ALF Patients"],"prefix":"10.1002","volume":"98","author":[{"given":"Siyu","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory The Affiliated Guangji Hospital of Soochow University Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhi","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory The Affiliated Guangji Hospital of Soochow University Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Anhui Province Key Laboratory of Immunology in Chronic Diseases, Research Center of Laboratory, School of Laboratory Bengbu Medical University Bengbu Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyi","family":"Ji","sequence":"additional","affiliation":[{"name":"Anhui Province Key Laboratory of Immunology in Chronic Diseases, Research Center of Laboratory, School of Laboratory Bengbu Medical University Bengbu Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Xiang","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0087-3744","authenticated-orcid":false,"given":"Jian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University Suzhou Jiangsu China"},{"name":"Suzhou Key Laboratory of Intelligent Critical Illness Biomarkers Translational Research Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University Suzhou Jiangsu China"},{"name":"Suzhou Key Laboratory of Intelligent Critical Illness Biomarkers Translational Research Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/4818435"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14060602"},{"issue":"7","key":"e_1_2_11_4_1","first-page":"578","article-title":"The Gut Microbiota in Elderly Patients With Acute Hepatitis E Infection","volume":"13","author":"Li M.","year":"2025","journal-title":"Journal of Clinical and Translational 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Nomogram for Patients With Hepatitis E Virus\u2010Related Acute Liver Failure: A Multicenter Study in China","volume":"9","author":"Wu J.","year":"2021","journal-title":"Journal of Clinical and Translational Hepatology"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.005"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2022.194814"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI188363"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.76756"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-023-02734-w"},{"key":"e_1_2_11_26_1","first-page":"14","article-title":"Reactive Oxygen Species Promotion Drives Auranofin's Antiviral Activity Against Hepatitis E Virus","volume":"22","author":"Tiller K.","year":"2022","journal-title":"Journal of 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