{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:07:31Z","timestamp":1790086051285,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cervical cancer remains a major public health challenge in Brazil. A molecular testing for human papillomavirus (HPV) was incorporated into the national screening program, current strategies prioritize HPV\u201016 and HPV\u201018, potentially overlooking other high\u2010risk genotypes circulating regionally. This cross\u2010sectional study evaluated HPV prevalence and genotype distribution among 8073 women in routine cervical screening and a separately recruited research cohort of sexually active women aged 15\u201325 years in 25 municipalities in southern Esp\u00edrito Santo, Brazil, from September 2024 to September 2025. Cervicovaginal samples were tested using the Allplex HPV28 real\u2010time quantitative PCR assay, which detects 28 HPV genotypes. Sociodemographic and behavioral data were collected via standardized questionnaires and vaccination status was verified for women aged 15\u201325 years using official records. Associations were analyzed using odds ratios (ORs) and 95% confidence intervals (CIs). Overall HPV prevalence was 27.9%, increasing to 57.0% among those aged 15\u201325 years. Carcinogenic genotypes comprised 43.4% of infections. The most prevalent relevant genotypes were HPV\u201053 (3.6%), HPV\u201068 (3.1%), HPV\u201052 (2.9%), HPV\u201016 (2.9%), and HPV\u201058 (2.3%). Multiple carcinogenic\/probable or possible carcinogenic infections occurred in 48.5% of HPV\u2010positive cases, with HPV\u201052, HPV\u201053, and HPV\u201068 forming a central coinfection cluster. Among women aged 15\u201325 years, 30.4% were vaccinated; no vaccine\u2010covered genotypes were detected in vaccinated women, compared with 6.4% in unvaccinated women (OR, 0.17; 95% CI, 0.009\u20133.08;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.18). Non\u201016\/18 genotypes predominate in this population, but the two most prevalent (HPV\u201053 and HPV\u201068) carry comparatively low attributable risk for invasive cervical cancer under current global classifications, whereas genotypes with established high carcinogenic potential (16, 18, 31, 33, 35, 45, 52, and 58) accounted for only 31.5% of detected infections. These findings support continued regional genotype surveillance and vaccine\u2010impact monitoring but, in the absence of histological or invasive\u2010cancer outcome data from this population, do not by themselves justify changes to screening panels or vaccine composition based on prevalence alone.\n                  <\/jats:p>","DOI":"10.1002\/jmv.71140","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:52:26Z","timestamp":1789836746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regional Diversity of Human Papillomavirus Genotypes in Southeastern Brazil: Implications for Cervical Cancer Screening"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0401-5002","authenticated-orcid":false,"given":"D\u00e9bora De'nadai","family":"Dalvi","sequence":"first","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade do Esp\u00edrito Santo Laborat\u00f3rio Central de Sa\u00fade P\u00fablica do Estado do Esp\u00edrito Santo Vit\u00f3ria Esp\u00edrito Santo Brasil"},{"name":"N\u00facleo de Doen\u00e7as Infecciosas Federal University of Esp\u00edrito Santo Vit\u00f3ria Esp\u00edrito Santo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria Gon\u00e7alves","family":"Cruz","sequence":"additional","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade do Esp\u00edrito Santo Laborat\u00f3rio Central de Sa\u00fade P\u00fablica do Estado do Esp\u00edrito Santo Vit\u00f3ria Esp\u00edrito Santo Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla Santos","family":"de Oliveira Rocha","sequence":"additional","affiliation":[{"name":"Superintend\u00eancia Regional de Sa\u00fade de Cachoeiro de Itapemirim Secretaria de Estado da Sa\u00fade do Esp\u00edrito Santo Cachoeiro de Itapemirim Esp\u00edrito Santo Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emarillene Rosa","family":"dos Passos Segantine","sequence":"additional","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade do Esp\u00edrito Santo Laborat\u00f3rio Central de Sa\u00fade P\u00fablica do Estado do Esp\u00edrito Santo Vit\u00f3ria Esp\u00edrito Santo Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Grillo","sequence":"additional","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade do Esp\u00edrito Santo Programa Estadual de Imuniza\u00e7\u00e3o Vit\u00f3ria Esp\u00edrito Santo Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaqueline Pegoretti","family":"Goulart","sequence":"additional","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade do Esp\u00edrito Santo Laborat\u00f3rio Central de Sa\u00fade P\u00fablica do Estado do Esp\u00edrito Santo Vit\u00f3ria Esp\u00edrito Santo Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lica Espinosa","family":"Miranda","sequence":"additional","affiliation":[{"name":"N\u00facleo de Doen\u00e7as Infecciosas Federal University of Esp\u00edrito Santo Vit\u00f3ria Esp\u00edrito Santo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0675-110X","authenticated-orcid":false,"given":"Rodrigo","family":"Ribeiro\u2010Rodrigues","sequence":"additional","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade do Esp\u00edrito Santo Laborat\u00f3rio Central de Sa\u00fade P\u00fablica do Estado do Esp\u00edrito Santo Vit\u00f3ria Esp\u00edrito Santo Brasil"},{"name":"N\u00facleo de Doen\u00e7as Infecciosas Federal University of Esp\u00edrito Santo Vit\u00f3ria Esp\u00edrito Santo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_10_3_1","unstructured":"Instituto Nacional de C\u00e2ncer Estimativa 2023: incid\u00eancia de c\u00e2ncer no Brasil(INCA 2023) [National Cancer Institute Estimate 2023: Cancer incidence in Brazil (INCA. 2023)] https:\/\/www.inca.gov.br\/publicacoes\/livros\/estimativa-2023-incidencia-de-cancer-no-brasil."},{"key":"e_1_2_10_4_1","unstructured":"S.Dell'Antonio A.Del Caro Sulti C.Souza Guerra de et al. Boletim epidemiol\u00f3gico sobre o c\u00e2ncer do colo do \u00fatero \u2212 2025(Secretaria de Estado da Sa\u00fade do Esp\u00edrito Santo 2025) [Epidemiological bulletin on cervical cancer \u2010 2025 (Espirito Santo State Department of 2025) Health] https:\/\/saude.es.gov.br\/Media\/sesa\/DANTS\/Boletim%20Epidemiol%C3%B3gico%20sobre%20C%C3%A2ncer%20do%20Colo%20do%20%C3%9Atero.pdf."},{"key":"e_1_2_10_5_1","unstructured":"Instituto Nacional de C\u00e2ncer Dados e n\u00fameros sobre c\u00e2ncer do colo do \u00fatero: relat\u00f3rio anual 2022(INCA 2022) National Cancer Institute Data and figures about cervical cancer: 2022 annual report (INCA 2022)] https:\/\/www.inca.gov.br\/utero."},{"key":"e_1_2_10_6_1","unstructured":"Instituto Nacional de C\u00e2ncer Atlas on\u2010line de mortalidade(INCA 2020) National Institute of Cancer Online Mortality Atlas (INCA 2020)] https:\/\/www.inca.gov.br\/MortalidadeWeb."},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvr.2023.200258"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pvr.2016.05.004"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-025-02855-y"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-025-06299-1"},{"key":"e_1_2_10_11_1","unstructured":"Instituto Nacional de C\u00e2ncer Jos\u00e9 Alencar Gomes da Silva Coordena\u00e7\u00e3o de Preven\u00e7\u00e3o e Vigil\u00e2ncia. Divis\u00e3o de Detec\u00e7\u00e3o Precoce e Apoio \u00e0 Organiza\u00e7\u00e3o de Rede.Diretrizes brasileiras para o rastreamento do cancer do colo do \u00fatero 2 Edi\u00e7\u00e3o [National Cancer Institute Prevention and Surveillance Coordination. Division of Early Detection and Network Organization Support. Brazilian Guidelines for cervical cancer screening 2nd Ed] (2016)."},{"key":"e_1_2_10_12_1","unstructured":"BRAZIL Ministry of Health Joint Ordinance SAES\/SECTIC #13 July 29 2025. Brazilian Guidelines for Cervical Cancer Screening: Part I \u2010 Organized Screening using Molecular Tests for Detection of Oncogenic HPV DNA.https:\/\/www.gov.br\/saude\/pt-br\/assuntos\/pcdt\/r\/rastreamento-cancer-do-colo-do-utero\/view."},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0104-42302011000400017"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-015-0017-x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2024.1353845"},{"key":"e_1_2_10_16_1","first-page":"e955","article-title":"Global Prevalence of Cervical Human Papillomavirus in Women Aged 50 Years and Older With Normal Cytology: A Systematic Review and Meta\u2010Analysis","volume":"5","author":"Osmani V.","year":"2024","journal-title":"Lancet Microbe"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2024-017309"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01097-3"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.7316"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-09126-3"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-022-06653-7"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-025-02904-6"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-023-08634-w"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-025-00709-4"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000920"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-53271-1"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1004304"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70187-1"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2020.11.076"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1362770"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-025-00643-"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.71140","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.71140","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.71140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:51:36Z","timestamp":1790085096000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.71140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/jmv.71140"],"URL":"https:\/\/doi.org\/10.1002\/jmv.71140","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71140"}}