{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:38:54Z","timestamp":1792618734408,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201010\u2010IAHU\u201003"],"award-info":[{"award-number":["ANR\u201010\u2010IAHU\u201003"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Lenacapavir and fostemsavir, two recently approved anti\u2010HIV\u20101 agents, are promising options for people with difficult\u2010to\u2010treat HIV; however, real\u2010world data remain limited. This study aimed to describe the epidemiological, clinical, and virological profiles of people receiving combination antiretroviral regimens, including lenacapavir and\/or fostemsavir. This retrospective study included adults living with HIV\u20101 treated by lenacapavir and\/or fostemsavir in our center (Marseille, France), between January 2023 and June 2024, with follow\u2010up continuing until July 2025. Clinical and biological data, including genotypic drug resistance testing and therapeutic drug monitoring, were extracted from electronic health records. The study included 21 people with HIV\u20101 (14 men; mean age, 56 years), representing 1.0% of our active HIV cohort in 2023 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092,126). Virological and immunological failure and treatment intensification were the main reasons for switching therapy. Before switching, viral load was detectable in 11 persons; 8 (73%) achieved undetectable viral load at 24 months, whereas 3 (27%) nonadherent people with lower CD4 nadirs, higher baseline viral loads, and lower baseline CD4 counts remained persistently viremic. All three developed high\u2010level genotypic resistance, including M426L and\/or S375T for fostemsavir (two people) and Q67H, K70R, N74S, and\/or A105AT for lenacapavir (two people). One developed resistance to both drugs. In one of these 3 persistently viremic PWH, a dual\u2010injectable rescue regimen combining lenacapavir and cabotegravir achieved viral suppression at 33 months with maintenance through the end of follow\u2010up, bringing the success rate to 9 out of 11 (82%) among PWH who were viremic at baseline. No severe lenacapavir\u2010 or fostemsavir\u2010related adverse events were observed. This small real\u2010world study supports the effectiveness and safety of lenacapavir and\/or fostemsavir in people with multidrug\u2010resistant HIV and variable adherence. All adherent people achieved viral suppression, whereas drug\u2010resistant HIV\u20101 emerged in three people with poor adherence. A dual\u2010injectable rescue regimen may represent a last\u2010resort option in selected complex cases. Similar real\u2010world studies should be expanded, and adherence support should be strengthened.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.71149","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T11:12:14Z","timestamp":1789125134000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Experience With Lenacapavir and\/or Fostemsavir as Emerging Therapies for the Management of Multidrug\u2010Resistant HIV\u20101 in Southeastern France"],"prefix":"10.1002","volume":"98","author":[{"given":"Syrine","family":"Boujamline","sequence":"first","affiliation":[{"name":"IHU Mediterran\u00e9e Infection Marseille France"},{"name":"AP\u2010HM, H\u00f4pital de la Timone Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Boschi","sequence":"additional","affiliation":[{"name":"IHU Mediterran\u00e9e Infection Marseille France"},{"name":"AP\u2010HM, H\u00f4pital de la Timone Marseille France"},{"name":"Aix\u2010Marseille Univ Microbes Evolution PHylogeny and Infection (MEPHI), UR D\u2010258 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8881-9414","authenticated-orcid":false,"given":"Hugo","family":"Bes\u2010Barlandier","sequence":"additional","affiliation":[{"name":"IHU Mediterran\u00e9e Infection Marseille France"},{"name":"AP\u2010HM, H\u00f4pital de la Timone Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Tomei","sequence":"additional","affiliation":[{"name":"IHU Mediterran\u00e9e Infection Marseille France"},{"name":"AP\u2010HM, H\u00f4pital de la Timone Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelie","family":"Menard","sequence":"additional","affiliation":[{"name":"IHU Mediterran\u00e9e Infection Marseille France"},{"name":"AP\u2010HM, H\u00f4pital de la Timone Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saadia","family":"Mokhtari","sequence":"additional","affiliation":[{"name":"IHU Mediterran\u00e9e Infection Marseille France"},{"name":"AP\u2010HM, H\u00f4pital de la Timone Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Ravaux","sequence":"additional","affiliation":[{"name":"IHU Mediterran\u00e9e Infection Marseille France"},{"name":"AP\u2010HM, H\u00f4pital de la Timone Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yacine","family":"Belkhir","sequence":"additional","affiliation":[{"name":"IHU Mediterran\u00e9e Infection Marseille France"},{"name":"AP\u2010HM, H\u00f4pital de la Timone Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadege","family":"Neant","sequence":"additional","affiliation":[{"name":"AP\u2010HM, H\u00f4pital de la Timone Marseille France"},{"name":"Laboratoire de Pharmacocinetique et de Toxicologie H\u00f4pital de la Timone, APHM Marseille France"},{"name":"Unit\u00e9 des Virus \u00c9mergents (UVE: Aix\u2010Marseille Univ, Universit\u00e0 di Corsica, IRD 190, Inserm 1207, IRBA)  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0943-9648","authenticated-orcid":false,"given":"Caroline","family":"Solas","sequence":"additional","affiliation":[{"name":"AP\u2010HM, H\u00f4pital de la Timone Marseille France"},{"name":"Laboratoire de Pharmacocinetique et de Toxicologie H\u00f4pital de la Timone, APHM Marseille France"},{"name":"Unit\u00e9 des Virus \u00c9mergents (UVE: Aix\u2010Marseille Univ, Universit\u00e0 di Corsica, IRD 190, Inserm 1207, IRBA)  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6285-0308","authenticated-orcid":false,"given":"Philippe","family":"Colson","sequence":"additional","affiliation":[{"name":"IHU Mediterran\u00e9e Infection Marseille France"},{"name":"AP\u2010HM, H\u00f4pital de la Timone Marseille France"},{"name":"Aix\u2010Marseille Univ Microbes Evolution PHylogeny and Infection (MEPHI), UR D\u2010258 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5556-6947","authenticated-orcid":false,"given":"Matthieu","family":"Million","sequence":"additional","affiliation":[{"name":"IHU Mediterran\u00e9e Infection Marseille France"},{"name":"AP\u2010HM, H\u00f4pital de la Timone Marseille France"},{"name":"Aix\u2010Marseille Univ Microbes Evolution PHylogeny and Infection (MEPHI), UR D\u2010258 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Global HIV & AIDS Statistics \u2014 Fact Sheet | UNAIDS [Internet]. 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