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To characterize the post\u2010COVID\u201019 humoral immune landscape in China, we conducted a cross\u2010sectional study evaluating cross\u2010neutralizing antibody profile and associated epidemiological factors in a Chinese cohort. Serum samples and epidemiological questionnaire data were collected from 273 convalescent volunteers. SARS\u2010CoV\u20102 infection history, vaccination background, and persistent symptoms were obtained via structured surveys. Serum neutralizing antibody (NAb) titers were measured against pseudoviruses representing B.1, BA.2, BA.5, XBB.1.16, JN.1, and KP.3.1.1. Associations of infection frequency, vaccination status, and epidemic era on NAb responses were evaluated. Persistent symptoms lasting \u2265\u200930 days were reported by 58.97% of participants, most commonly fatigue\/malaise (32.60%) and chronic cough (23.08%). NAb titers remained high against B.1, BA.2, and BA.5, a marked 5\u2010 to 27\u2010fold reduction was observed against XBB.1.16, JN.1, and KP.3.1.1. Neutralization against KP.3.1.1 showed the greatest reduction, with 42.90% of serum samples below the lower limit of detection. Compared with individuals with one infection, those with repeated infections showed relatively higher titers against later Omicron sub\u2010variants, particularly XBB.1.16, JN.1, and KP.3.1.1, whereas neutralization against earlier variants was not consistently increased neutralizing profiles also varied by epidemic era of infection, although some subgroup analyzes were limited by small sample sizes. Together, these findings define the cross\u2010NAb landscape in a real\u2010world Chinese population after a 3\u2010year zero\u2010COVID strategy. Despite modest broadening of humoral immunity following multiple exposures, antigenic divergence of emerging Omicron sub\u2010variants continues to limit cross\u2010protection, supporting the need for variant\u2010adapted vaccination strategies.<\/jats:p>","DOI":"10.1002\/jmv.71153","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T14:27:01Z","timestamp":1789482421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cross\u2010Neutralization Responses and Persistent Symptoms After SARS\u2010CoV\u20102 Breakthrough Infections"],"prefix":"10.1002","volume":"98","author":[{"given":"Ting","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Epidemiology School of Public Health, Cheeloo College of Medicine, Shandong University Jinan 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