{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:38:38Z","timestamp":1792618718191,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Human adenoviruses (HAdVs) are characterized by extensive type diversity and widespread preexisting immunity, yet whether natural HAdV infection induces immune imprinting, the tendency of the immune system to preferentially recall responses to the first encountered antigenic variant, remains unclear. In this cross\u2010sectional study of 1150 adults, neutralizing antibody (NT\n                    <jats:sub>50<\/jats:sub>\n                    ) profiles against HAdV\u20103, \u20105, and \u20107 were determined, and multi\u2010positive sera were analyzed by cross\u2010adsorption neutralization and the cross\u2010antibody contribution index (CACI). Seroprevalences were 69.8% (HAdV\u20103), 63.0% (HAdV\u20105), and 51.9% (HAdV\u20107); multi\u2010positive sera accounted for 64% and increased with age. Cross\u2010adsorption revealed asymmetric heterotypic neutralization: HAdV\u20103 adsorption markedly reduced anti\u2010HAdV\u20107 activity in HAdV\u20103\u2010dominant sera, whereas HAdV\u20107 adsorption produced only a mild effect on anti\u2010HAdV\u20103 activity; cross\u2010neutralization involving HAdV\u20105 was minimal. The median CACI for HAdV\u20103 to HAdV\u20107 was 0.81, compared with 0.22 for HAdV\u20107 to HAdV\u20103 and 0.04 for cross\u2010species B\u2013C comparisons. Imprinting\u2010like signatures were most frequent in HAdV\u20103\u2010dominant sera (85%) and increased with age. These findings provide functional serological evidence for directional, type\u2010dependent imprinting\u2010like responses in HAdV infection and underscore the need to assess antibody quality and immune history, beyond neutralizing titers alone, in the design of adenoviral vector\u2010based interventions.\n                  <\/jats:p>","DOI":"10.1002\/jmv.71154","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:44:37Z","timestamp":1789209877000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Imprinting\u2010Like Serological Signatures in Human Adenovirus Infections Revealed by Cross\u2010Adsorption Neutralization Profiling of HAdV\u20103, HAdV\u20105, and HAdV\u20107"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4749-8822","authenticated-orcid":false,"given":"Yingchen","family":"Wang","sequence":"first","affiliation":[{"name":"College of Public Health Harbin Medical University Harbin Heilongjiang Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Public Health Harbin Medical University Harbin Heilongjiang Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqi","family":"Song","sequence":"additional","affiliation":[{"name":"College of Public Health Harbin Medical University Harbin Heilongjiang Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuo","family":"Dong","sequence":"additional","affiliation":[{"name":"College of Public Health Harbin Medical University Harbin Heilongjiang Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"College of Public Health Jiamusi University Jiamusi Heilongjiang Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyu","family":"Yuan","sequence":"additional","affiliation":[{"name":"College of Public Health Harbin Medical University Harbin Heilongjiang Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8795-1284","authenticated-orcid":false,"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Public Health Harbin Medical University Harbin Heilongjiang Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines6010030"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.DMIH2-0020-2015"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.24.15265-15276.2005"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00354-11"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23325"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23546"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14122727"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31605-6"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.07076-11"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.04.008"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900398"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002802"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01826-10"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3014"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI162192"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.08.003"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad0522"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan6836"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.01.018"},{"key":"e_1_2_10_21_1","article-title":"Seroprevalence of Neutralizing Antibodies to Human Adenoviruses Type 3, 4, 7, 14, 21 and 55 in Healthy Adults in Southern China","volume":"2","author":"Zhang Q.","year":"2013","journal-title":"Emerging Microbes & Infections"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.05.025"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02023-06"},{"key":"e_1_2_10_24_1","first-page":"367","article-title":"Identification of a Critical Neutralizing Epitope in the Hexon of Human Adenovirus Type 3","volume":"433","author":"Tian X.","year":"2012","journal-title":"Virology"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06254-11"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.70.3.1836-1844.1996"},{"key":"e_1_2_10_27_1","first-page":"6866","article-title":"Adenovirus Serotype 5\u2010Specific Neutralizing Antibodies Target the Hexon Hypervariable Regions","volume":"84","author":"Chen H.","year":"2010","journal-title":"Journal of Virology"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2016.12.004"},{"key":"e_1_2_10_29_1","article-title":"Antigenic Seniority: A Mechanism for the Antibody Response to Influenza Vaccination","volume":"9","author":"Miller M. S.","year":"2013","journal-title":"PLoS Pathogens"},{"key":"e_1_2_10_30_1","first-page":"110","article-title":"Epidemical Features of Human Adenovirus Type 7 Respiratory Infections in China","volume":"69","author":"Wo Y.","year":"2015","journal-title":"Journal of Clinical Virology"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.4161\/hv.29594"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.71154","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.71154","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.71154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:57:31Z","timestamp":1792616251000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.71154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/jmv.71154"],"URL":"https:\/\/doi.org\/10.1002\/jmv.71154","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-06-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71154"}}