{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:38:38Z","timestamp":1792618718169,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hepatitis A virus (HAV) and hepatitis E virus (HEV) are enterically transmitted hepatotropic viruses with heterogeneous epidemiological patterns in Argentina. Data simultaneously evaluating both infections in blood donor populations are limited. We conducted a multicentre cross\u2010sectional study including 848 blood donors from three Argentine blood banks between September 2024 and August 2025. Total antiHAV and antiHEV IgG antibodies were determined by ELISA. Sociodemographic, occupational, dietary, and donation\u2010related variables were collected using standardized questionnaires. Logistic regression models with restricted cubic splines were applied to assess age\u2010specific associations and inter\u2010centre variability. Overall antiHAV seroprevalence was 62.9% (95% CI: 59.6\u201366.0) and antiHEV seroprevalence was 12.1% (95% CI: 10.1\u201314.5), with significant differences between blood banks. AntiHAV seropositivity showed a non\u2010linear association with age and a significant interaction with blood bank (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), whereas no independent associations with questionnaire\u2010derived exposures were identified after adjustment. AntiHEV seropositivity was not associated with age but remained independently associated with occupational food handling (aOR 1.94; 95% CI: 1.04\u20133.51) and game meat consumption (aOR 2.19; 95% CI: 1.24\u20133.81). Dual seropositivity (6.5%) was consistent with statistical independence between infections. AntiHAV and antiHEV seroprevalence in this accessible adult donor population provides updated epidemiological information from three Argentine blood banks. The study also adds data on joint seroprevalence and associated factors, contributing to the understanding of HAV and HEV exposure patterns in this setting.\n                  <\/jats:p>","DOI":"10.1002\/jmv.71157","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:20:54Z","timestamp":1790076054000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Seroprevalence and Associated Factors of Hepatitis A Virus and Hepatitis E Virus Infection Among Blood Donors in Argentina: A Multicentre Study"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5634-122X","authenticated-orcid":false,"given":"Sara Noem\u00ed","family":"Vladimirsky","sequence":"first","affiliation":[{"name":"National Reference Laboratory for Viral Hepatitis National Institute of Infectious Diseases (INEI), ANLIS \u201cDr. Carlos G. Malbr\u00e1n Autonomous City of Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2181-7795","authenticated-orcid":false,"given":"Juan Ignacio","family":"Degiuseppe","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Norovirus and Rotavirus National Institute of Infectious Diseases (INEI), ANLIS \u201cDr. Carlos G. Malbr\u00e1n Autonomous City of Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio Oscar","family":"Otegui","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Viral Hepatitis National Institute of Infectious Diseases (INEI), ANLIS \u201cDr. Carlos G. Malbr\u00e1n Autonomous City of Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Sergio","family":"Brajterman","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Viral Hepatitis National Institute of Infectious Diseases (INEI), ANLIS \u201cDr. Carlos G. Malbr\u00e1n Autonomous City of Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1552-0276","authenticated-orcid":false,"given":"Carolina","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Laboratory of Transfusion\u2010Transmissible Infections Regional Hemotherapy Center, Prof. Dr. Juan P. Garrahan Hospital Autonomous City of Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanza","family":"Lapera","sequence":"additional","affiliation":[{"name":"Laboratory of Transfusion\u2010Transmissible Infections Regional Hemotherapy Center, Prof. Dr. Juan P. Garrahan Hospital Autonomous City of Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3100-0859","authenticated-orcid":false,"given":"Diego Anibal","family":"Dominguez","sequence":"additional","affiliation":[{"name":"Regional Hemotherapy Center of Northern Santa Cruz, Hospital Zonal Caleta Olivia \u201cPadre Pedro Tardivo Santa Cruz Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Weisz","sequence":"additional","affiliation":[{"name":"Central Laboratory National Hospital Prof. Dr. Alejandro Posadas Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Nonaka","sequence":"additional","affiliation":[{"name":"Hemotherapy Service, Department of Diagnosis and Treatment National Hospital Prof. Dr. Alejandro Posadas Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy Rosana","family":"Altabert","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Viral Hepatitis National Institute of Infectious Diseases (INEI), ANLIS \u201cDr. Carlos G. Malbr\u00e1n Autonomous City of Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Alejandra","family":"Vazquez","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Viral Hepatitis National Institute of Infectious Diseases (INEI), ANLIS \u201cDr. Carlos G. Malbr\u00e1n Autonomous City of Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia Soledad","family":"Soto","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Viral Hepatitis National Institute of Infectious Diseases (INEI), ANLIS \u201cDr. Carlos G. Malbr\u00e1n Autonomous City of Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanina","family":"Zelaya","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Viral Hepatitis National Institute of Infectious Diseases (INEI), ANLIS \u201cDr. Carlos G. Malbr\u00e1n Autonomous City of Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanina Belen Miranda","family":"Arias","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Viral Hepatitis National Institute of Infectious Diseases (INEI), ANLIS \u201cDr. Carlos G. Malbr\u00e1n Autonomous City of Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2236-9220","authenticated-orcid":false,"given":"Mar\u00eda Laura","family":"Minassian","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Viral Hepatitis National Institute of Infectious Diseases (INEI), ANLIS \u201cDr. Carlos G. 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