{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:43:02Z","timestamp":1792417382456,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Echovirus 19 (E19) is a rarely reported non\u2010polio enterovirus (NPEV), although it has been associated with a spectrum of severe syndromes, including encephalitis, meningitis, and multisystem hemorrhagic disease in infants. Moreover, Echovirus 19 has been detected in patients with acute flaccid paralysis (AFP), suggesting a potential association between viral infection and CNS damage. Here we describe molecular epidemiology of Echovirus 19 in Russia and Central Asia from 1999 to 2024 using data on poliomyelitis surveillance. Echovirus 19 accounted for no more than 4% of annual NPEV isolates, however, in 2022 abundance rate dramatically increased making this virus the most frequently isolated NPEV from AFP cases (14.3% of NPEV\u2010positive AFP cases). Phylogenetic analysis revealed that contemporary (2020\u20132025) regional isolates formed a distinct, well\u2010supported clade sharing a common ancestor with Echovirus 19 variants isolated from AFP cases in Iran and Pakistan in 2013. Notably, these recent isolates lack sustained country\u2010specific sublineages indicating ongoing cross\u2010border circulation. A novel A83S mutation in the BC\u2010loop of the VP1 antigenic region was identified in 75% isolates collected in 2022\u20132025. The emergence of this variant highlights the need for continued surveillance and further investigation into the Echovirus 19 possible role in neurological diseases.<\/jats:p>","DOI":"10.1002\/jmv.71168","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:04:38Z","timestamp":1791450278000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Echovirus 19 Molecular Epidemiology in Russia and Some Central Asian Countries in 1999\u20132024"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7211-0076","authenticated-orcid":false,"given":"Elizaveta V.","family":"Yakovchuk","sequence":"first","affiliation":[{"name":"Chumakov Federal Scientific Center for Research and Development of Immune\u2010and\u2010Biological Preparations of RAS (Institute of Poliomyelitis) Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Yu.","family":"Shustova","sequence":"additional","affiliation":[{"name":"Chumakov Federal Scientific Center for Research and Development of Immune\u2010and\u2010Biological Preparations of RAS (Institute of Poliomyelitis) Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liudmila N.","family":"Galitzina","sequence":"additional","affiliation":[{"name":"Federal Budgetary Science Institution \u00abAcademician I.N. Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology\u00bb Nizhny Novgorod Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1153-0958","authenticated-orcid":false,"given":"Evgenia V.","family":"Karpova","sequence":"additional","affiliation":[{"name":"Chumakov Federal Scientific Center for Research and Development of Immune\u2010and\u2010Biological Preparations of RAS (Institute of Poliomyelitis) Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga Yu.","family":"Baykova","sequence":"additional","affiliation":[{"name":"Chumakov Federal Scientific Center for Research and Development of Immune\u2010and\u2010Biological Preparations of RAS (Institute of Poliomyelitis) Moscow 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Epidemiological Welfare and Public Health Committee of the Republic of Uzbekistan Tashkent Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7079-2430","authenticated-orcid":false,"given":"Botirjon","family":"Kurbanov","sequence":"additional","affiliation":[{"name":"Sanitary and Epidemiological Welfare and Public Health Committee of the Republic of Uzbekistan Tashkent Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3417-3631","authenticated-orcid":false,"given":"Armen K.","family":"Shakaryan","sequence":"additional","affiliation":[{"name":"Chumakov Federal Scientific Center for Research and Development of Immune\u2010and\u2010Biological Preparations of RAS (Institute of Poliomyelitis) Moscow Russia"},{"name":"IKB No.1 DZM Moscow Russia"},{"name":"Pirogov Russian National Research Medical University Moscow 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