{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:56:07Z","timestamp":1792418167940,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LTGY23D060001"],"award-info":[{"award-number":["LTGY23D060001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tumors often exhibit immunosuppressive microenvironments (TMEs) and present as immunologically \u201ccold.\u201d Oncolytic viruses (OVs), particularly engineered vaccinia viruses (oncoVVs), are an encouraging therapy that directly lyses cancer cells and reprograms the TME. In this study, we evaluated the therapeutic potential of an oncolytic vaccinia virus expressing human C\u2010type lectin domain family 2 member A (oncoVV\u2010CLEC2A) in melanoma and ovarian cancer cells. OncoVV\u2010CLEC2A elevated reactive oxygen species (ROS) levels, suppressed Nrf2\u2010mediated antioxidant responses, and triggered autophagy. These changes promoted cytokine production (IL\u20106, IFN\u2010\u03b1\/\u03b2\/\u03b3, TNF\u2010\u03b1) via activation of AP\u20101 and IRF3\/7. In a B16\u2010F10 melanoma model, oncoVV\u2010CLEC2A increased serum levels of IFN\u2010\u03b3, accompanied by augmented infiltration of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells and activation of NK cells. Taken together, oncoVV\u2010CLEC2A reshapes the TME by intensifying oxidative stress and autophagic activity, effectively turning \u201ccold\u201d tumors \u201chot.\u201d Notably, the mutual reinforcement between ROS production and autophagy activation not only enhances viral replication but also triggers cytokine\u2010mediated immunity.\n                  <\/jats:p>","DOI":"10.1002\/jmv.71174","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:28:57Z","timestamp":1792416537000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oncolytic Vaccinia Virus Armed With CLEC2A Enhances Antitumor Immunity via ROS\u2010Autophagy Feedback Loop and Cytokine Activation"],"prefix":"10.1002","volume":"98","author":[{"given":"Jiawei","family":"Su","sequence":"first","affiliation":[{"name":"Zhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, College of Life Sciences and Medicine Zhejiang Sci\u2010Tech University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlian","family":"Zhai","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, College of Life Sciences and Medicine Zhejiang Sci\u2010Tech University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Li","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, College of Life Sciences and Medicine Zhejiang Sci\u2010Tech University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1519-5299","authenticated-orcid":false,"given":"Ruikang","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, College of Life Sciences and Medicine Zhejiang Sci\u2010Tech University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jili","family":"Zhu","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, College of Life Sciences and Medicine Zhejiang Sci\u2010Tech University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5349-5850","authenticated-orcid":false,"given":"Kan","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, College of Life Sciences and Medicine Zhejiang Sci\u2010Tech University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4952-8140","authenticated-orcid":false,"given":"Yanrong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, College of Life Sciences and Medicine Zhejiang Sci\u2010Tech University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8072-0363","authenticated-orcid":false,"given":"Ting","family":"Ye","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, College of Life Sciences and Medicine Zhejiang Sci\u2010Tech University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2997-2511","authenticated-orcid":false,"given":"Gongchu","family":"Li","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, College of Life Sciences and Medicine Zhejiang Sci\u2010Tech University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ccell.2022.10.016","article-title":"Engineered T Cell Therapy for Viral and Non\u2010Viral Epithelial Cancers","volume":"41","author":"Norberg S. 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