{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T19:36:46Z","timestamp":1792870606478,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Children with lymphoreticular malignancies are highly vulnerable to respiratory viral infections (RVIs) because of disease\u2010 and chemotherapy\u2010related immunosuppression, yet data on their epidemiology, clinical spectrum, and outcomes from resource\u2010limited settings remain scarce. This study aimed to characterize the seasonal distribution, clinical presentation, and outcomes of RVIs other than SARS\u2010CoV\u20102 in febrile children with lymphoreticular malignancies at a tertiary care centre in India. In this prospective, descriptive, cross\u2010sectional study (May 2023\u2013November 2024), 33 children under 12 years of age with lymphoreticular malignancies were enrolled at a tertiary care centre in Delhi, India, contributing 70 febrile episodes with respiratory symptoms. All episodes were screened for SARS\u2010CoV\u20102 by rapid antigen test at admission, independent of the viral PCR panel, and none tested positive. Nasopharyngeal swabs were analyzed by multiplex real\u2010time PCR (TRUPCR\u00ae Respiratory Viral Pathogen Panel Kit, 3B BlackBio, Bhopal, India; CFX96\u2122, Bio\u2010Rad, Hercules, CA, USA) targeting 18 other respiratory viral pathogens. Respiratory viruses were detected in 34% of episodes (24\/70). The most prevalent viruses identified were human coronavirus (HCoV \u03b1\/\u03b2, 21%), human rhinovirus (HRV, 17%), human parainfluenza virus type 3 (HPIV\u20103, 13%), influenza A (IAV,13%), and human adenovirus (HAdV, 13%). Co\u2010infections occurred in 13% of virus\u2010positive episodes, with HAdV being the predominant co\u2010pathogen. Upper respiratory tract infections (URTI) predominated (87%). Among virus\u2010positive episodes, breathlessness (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005), URTI\/LRTI classification (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), erythrocyte sedimentation rate (ESR;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and abnormal chest radiography (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) were significantly associated with viral status. Two patients (6%) died, both attributed to lower respiratory tract infection (LRTI) caused by human parainfluenza virus type 4 (HPIV\u20104). The remaining 66% of episodes were PCR\u2010negative. No SARS\u2010CoV\u20102 was detected in this cohort at any point during the study period. In approximately one\u2010third of febrile episodes of children with hematologic malignancies, a viral pathogen could be detected. Both fatalities in this cohort were associated with HPIV\u20104\u2010related LRTI; although the numbers are small, this finding warrants clinical attention and continued epidemiological surveillance in this population. Multiplex PCR supports targeted management; prospective, multicentre stewardship studies are needed.\n                  <\/jats:p>","DOI":"10.1002\/jmv.71180","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T11:46:37Z","timestamp":1792237597000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Respiratory Viral Infections in Febrile Children With Lymphoreticular Malignancies: A Single\u2010Centre Descriptive Study"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0635-2352","authenticated-orcid":false,"given":"Keerthana","family":"M R","sequence":"first","affiliation":[{"name":"Department of Microbiology University College of Medical Sciences (University of Delhi) &amp; Guru Teg Bahadur Hospital Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8117-2423","authenticated-orcid":false,"given":"Shukla","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Microbiology University College of Medical Sciences (University of Delhi) &amp; Guru Teg Bahadur Hospital Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9957-1556","authenticated-orcid":false,"given":"Charu","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Microbiology University College of Medical Sciences (University of Delhi) &amp; Guru Teg Bahadur Hospital Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7373-5679","authenticated-orcid":false,"given":"Pooja","family":"Dewan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University College of Medical Sciences (University of Delhi) &amp; Guru Teg Bahadur Hospital Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumpa","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Microbiology University College of Medical Sciences (University of Delhi) &amp; Guru Teg Bahadur Hospital Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2429-7913","authenticated-orcid":false,"given":"Praveen Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Microbiology University College of Medical Sciences (University of Delhi) &amp; Guru Teg Bahadur Hospital Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2499-8701","authenticated-orcid":false,"given":"Sajad Ahmad","family":"Dar","sequence":"additional","affiliation":[{"name":"Department of Nursing, College of Nursing and Health Sciences Jazan University Jazan Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60741-8"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2009.11.026"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9010051"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.5152\/TurkPediatriArs.2016.2757"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2014.01.006"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.4172\/2327-5073.1000137"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02294-07"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23272"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00210-07"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00733-10"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157398"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880018.2019.1631920"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.24953\/turkjped.2018.06.005"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001418"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.24953\/turkjpediatr.2024.4536"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31827bd619"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28570"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.723850"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25432"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.20515\/otd.1315573"},{"key":"e_1_2_12_22_1","first-page":"249","article-title":"Assessment of Respiratory Tract Viruses in Febrile Neutropenic Etiology in Children and Comparison With Healthy Children With Upper\/Lower Respiratory Tract Infection","volume":"8","author":"Turhan A. 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