{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:39:55Z","timestamp":1792420795618,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460388 to XW"],"award-info":[{"award-number":["82460388 to XW"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hepatocellular carcinoma (HCC) occurrence and progression are closely associated with hepatitis B virus (HBV) infection. Heat shock protein family A member 1B (HSPA1B), a key member of the heat shock protein 70 family, has attracted extensive attention in viral infection research, yet its specific function in HBV\u2010related HCC pathogenesis remains largely unknown. HSPA1B was identified as a cccDNA\u2010binding protein using the biotin\u2010avidin system, and its role in HBV infection and HCC progression was systematically investigated.\n                    <jats:italic>In vivo<\/jats:italic>\n                    experiments were performed using a mouse model established by tail vein injection of prcccDNA and pCMV\u2010KRAB\u2010Cre to evaluate the impact of HSPA1B on HBV transcription and replication. RNA sequencing was applied to HBV\u2010infected HepG2\u2010NTCP cells to analyze the differentially expressed genes regulated by HSPA1B, aiming to clarify the molecular mechanism underlying HSPA1B\u2010mediated promotion of HBV transcription and replication. Meanwhile, Western blot, RT\u2010qPCR, co\u2010immunoprecipitation and Transwell assays were used to explore the relationship between HSPA1B and HBV\u2010related HCC. We found that HSPA1B promoted HBV transcription and replication. Mechanistically, the increased expression of HSPA1B promoted HBV transcription and replication by downregulating SOX4 and enhancing the stability of the HBx protein. Further research indicated that HSPA1B can enhance the metastasis and invasion of HBx\u2010mediated HCC. Collectively, these results demonstrate a novel function of HSPA1B in regulating HBV transcription and HBV\u2010related HCC metastasis, indicating that HSPA1B may serve as a promising therapeutic target for HBV\u2010associated HCC.\n                  <\/jats:p>","DOI":"10.1002\/jmv.71181","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:44:51Z","timestamp":1792417491000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel cccDNA\u2010Binding Protein HSPA1B Promotes HBV Transcription and HBx\u2010Mediated HCC Metastasis via Downregulating SOX4"],"prefix":"10.1002","volume":"98","author":[{"given":"Yahui","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Tianjin Key Laboratory of Digestive Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), The Second Affiliated Hospital Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), The Second Affiliated Hospital Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), The Second Affiliated Hospital Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Affiliated Hospital of Zunyi Medical University Zunyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leirong","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), The Second Affiliated Hospital Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiameng","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), The Second Affiliated Hospital Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengtao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), The Second Affiliated Hospital Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1041-1829","authenticated-orcid":false,"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), The Second Affiliated Hospital Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"issue":"5","key":"e_1_2_14_2_1","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1053\/j.gastro.2023.01.033","article-title":"Global Epidemiology and Genetics of Hepatocellular Carcinoma","volume":"164","author":"Toh M. 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