{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T19:36:46Z","timestamp":1792870606362,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Torque teno virus (TTV) is a recognized marker of immune competence, but its relevance in severe bacterial infections is unclear. We evaluated prevalence, viral load, and clinical relevance of TTV viremia in complicated\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      infection (CSAI). In this ancillary analysis of two prospective pharmacokinetic cohort studies at a Swiss university hospital, stored plasma samples were tested for TTV DNA using TTV R\u2010GENE PCR, and cytokines were measured by multiplex immunoassay. Associations between TTV load, inflammatory biomarkers, and clinical outcomes (including 30\u2010day mortality) were assessed. Among 103 patients (median age 67.9 years; 85% with bloodstream infection), TTV viremia was detected in 76% at baseline with a median viral load of 2.85 log\n                      <jats:sub>10<\/jats:sub>\n                      copies\/mL (IQR 1.87\u20133.56). Levels remained stable over 1 week despite declining inflammatory markers. Baseline TTV load was numerically higher in 30\u2010day non\u2010survivors (3.53 vs. 2.83\u2009log\n                      <jats:sub>10<\/jats:sub>\n                      copies\/mL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.054) and not associated with mortality after adjusting for age, sex, and SOFA score (OR 1.29 per log\n                      <jats:sub>10<\/jats:sub>\n                      increase; 95% CI 0.82\u20132.02;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.268). TTV load was not associated with ICU admission, bacteremia duration, or length of stay. TTV viremia is common in CSAI but shows no significant association with inflammation or short\u2010term outcomes, suggesting limited value for risk stratification.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.71182","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T11:44:07Z","timestamp":1792237447000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Torque Teno Virus Viremia in Complicated\n                    <i>Staphylococcus aureus<\/i>\n                    Infection: Prevalence, Viral Load, and Associations With Inflammatory Markers and Clinical Outcomes"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4565-5740","authenticated-orcid":false,"given":"Fabian","family":"Ritter","sequence":"first","affiliation":[{"name":"Division of Internal Medicine University Hospital Basel Basel Switzerland"},{"name":"Division of Internal Medicine Inselspital, University Hospital Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6184-494X","authenticated-orcid":false,"given":"Stephan","family":"Moser","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine University Hospital Basel Basel Switzerland"},{"name":"Department of Clinical Research University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5654-9356","authenticated-orcid":false,"given":"Karoline","family":"Leuzinger","sequence":"additional","affiliation":[{"name":"Clinical Virology University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5439-957X","authenticated-orcid":false,"given":"Michael","family":"Osthoff","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine University Hospital Basel Basel Switzerland"},{"name":"Department of Clinical Research University of Basel Basel Switzerland"},{"name":"Division of Internal Medicine Kantonsspital Winterthur Winterthur Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy306"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-70972-5_1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00536-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.01.011"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-014-9716-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149901"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2019.03.004"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33909-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-023-07216-0"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","unstructured":"F.Haupenthal F.Herkner S.Kapps et al. \u201cAbstract Presentation at ERA 2026: Torque Teno Virus\u2010Guided vs. Standard Immunosuppression in Kidney Transplant Recipients: The TTVguideIT Randomised Controlled Trial \u201d 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Torque Teno Virus Viremia Predicts Long\u2010Term Mortality and Reflects Chronic Low\u2010Grade Inflammation (Inflammaging) in Geriatric Inpatients","volume":"2025","author":"Cianfruglia L.","journal-title":"Experimental Gerontology"}],"container-title":["Journal of Medical 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