{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T19:36:44Z","timestamp":1792870604324,"version":"4.5.0"},"reference-count":53,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The clinical utility of serum Golgi protein 73 (GP73) for evaluating hepatic fibrosis in hepatitis C virus (HCV) infection remains to be determined. We retrospectively enrolled 978 patients with serum GP73, aspartate\u2010to\u2010platelet ratio index (APRI), and Fibrosis\u20104 (FIB\u20104) measurements. Hepatic fibrosis was staged using vibration\u2010controlled transient elastography (VCTE) with cutoff values of \u2264\u20097.0, 7.1\u20139.4, 9.5\u201312.4, and \u2265\u200912.5\u2009kPa corresponding to F0\u2013F1, F2, F3, and F4. Distributions of GP73, APRI, and FIB\u20104 levels across fibrosis stages were compared using Kruskal\u2013Wallis tests. Areas under the receiver operating characteristic curves (AUROCs) were calculated and compared using DeLong tests, and optimal GP73 cutoff values were determined by maximal Youden indices. Multivariable linear regression was performed for factors associated with GP73 levels. Median GP73, APRI, and FIB\u20104 levels increased with advancing fibrosis stage (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Serum GP73 showed superior performance to APRI in discriminating \u2265\u2009F2 (AUROC 0.86 vs. 0.79,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), \u2265\u2009F3 (0.88 vs. 0.81,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and F4 (0.90 vs. 0.84,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002). GP73 showed better performance than FIB\u20104 for \u2265\u2009F2 (0.86 vs. 0.82,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005) and comparable performance for \u2265\u2009F3 (0.88 vs. 0.87,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.63) and F4 (0.90 vs. 0.89,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.72). Optimal GP73 cutoff values were 122, 159, and 174\u2009ng\/mL for \u2265\u2009F2, \u2265\u2009F3, and F4. Regression analysis demonstrated a significant association between fibrosis stage and GP73 levels. In conclusion, serum GP73 is a reliable and accurate noninvasive biomarker for staging hepatic fibrosis for HCV.\n                  <\/jats:p>","DOI":"10.1002\/jmv.71183","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:33:31Z","timestamp":1792416811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Golgi Protein 73 as a Noninvasive Marker of Hepatic Fibrosis in Chronic Hepatitis C Virus Infection"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7543-7547","authenticated-orcid":false,"given":"Yun\u2010Chu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Biomedical Park Hospital Hsin\u2010Chu 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Institute of Metabolism and Obesity Sciences Taipei Medical University Taipei Taiwan"},{"name":"TMU Research Center for Digestive Medicine Taipei Medical University Taipei Taiwan"},{"name":"Taipei Cancer Center Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Lin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Taipei City Hospital, Ren\u2010Ai Branch Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5800-1901","authenticated-orcid":false,"given":"Sheng\u2010Shun","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Kuan Tien General Hospital Taichung Taiwan"},{"name":"Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4629-4393","authenticated-orcid":false,"given":"Yu\u2010Lueng","family":"Shih","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Tri\u2010Service General Hospital National Defense Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9030-6086","authenticated-orcid":false,"given":"Cheng\u2010Yuan","family":"Peng","sequence":"additional","affiliation":[{"name":"Center for Digestive Medicine, Department of Internal Medicine China Medical University Hospital Taichung Taiwan"},{"name":"School of Medicine China Medical University Taichung 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