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A core clock mechanism in the mouse SCN appears to involve a transcriptional feedback loop in which <jats:italic>Period<\/jats:italic> (<jats:italic>Per<\/jats:italic>) and <jats:italic>Cryptochrome<\/jats:italic> (<jats:italic>Cry<\/jats:italic>) genes play a role in negative feedback. The circadian rhythm systems include photic entrainment, clock oscillation, and outputs of clock information such as melatonin production. In this experiment, we examined clock gene expression to determine whether circadian input, oscillation, and output are disrupted with aging. Circadian expression profiles of <jats:italic>rPer1<\/jats:italic>, <jats:italic>rPer2<\/jats:italic>, or <jats:italic>rCry1<\/jats:italic> mRNA were very similar in the SCN, the paraventricular nucleus of the hypothalamus (PVN), and the pineal body of young and aged (22\u201326 months) rats. On the other hand, the photic stimulation\u2010induced rapid expression of <jats:italic>Per1<\/jats:italic> and <jats:italic>Per2<\/jats:italic> in the SCN was reduced with aging. The present results suggest that the molecular mechanism of clock oscillation in the SCN, PVN, and pineal body is preserved against aging, whereas the impairment of <jats:italic>Per1<\/jats:italic> induction in the SCN after light stimulation may result in impaired behavioral photic entrainment in aged rats. J Neurosci. Res. 66:1133\u20131139, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.10010","type":"journal-article","created":{"date-parts":[[2004,10,28]],"date-time":"2004-10-28T12:11:22Z","timestamp":1098965482000},"page":"1133-1139","source":"Crossref","is-referenced-by-count":138,"title":["Circadian profile of <i>Per<\/i> gene mRNA expression in the suprachiasmatic nucleus, paraventricular nucleus, and pineal body of aged 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