{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:12Z","timestamp":1786978092133,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,11,30]],"date-time":"2001-11-30T00:00:00Z","timestamp":1007078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006310","name":"Swedish Medical Research Council","doi-asserted-by":"crossref","award":["4732"],"award-info":[{"award-number":["4732"]}],"id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006310","name":"Swedish Medical Research Council","doi-asserted-by":"crossref","award":["5980"],"award-info":[{"award-number":["5980"]}],"id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Axel and Margaret Axelsson-Johnson Foundation"},{"name":"Royal Physiographic Society"},{"name":"First of May Flower Annual Foundation"},{"name":"Linn\u00e9a and Josef Carlssons Foundation"},{"name":"Sven Jerring Foundation"},{"name":"Thelma Zoegas Foundation"},{"DOI":"10.13039\/501100006686","name":"Segerfalk Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006686","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004817","name":"Medical Faculty of Lund University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004817","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swedish Government"},{"name":"Lund University Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The effects of fetal asphyxia on cerebral function and development, involve the transition from fetal to neonatal life. Changes in cerebral glucose metabolism may be an early postnatal indicator of fetal asphyxia. The objective is to develop an experimental lamb model involving the transition from fetal to neonatal life and to examine the effect of\n                    <jats:italic>fetal<\/jats:italic>\n                    asphyxia with cerebral hypoxic ischemia on early\n                    <jats:italic>postnatal<\/jats:italic>\n                    cerebral glucose metabolism. Fetal asphyxia was induced by total umbilical cord occlusion in eight near\u2010term fetal lambs (134\u2013138 days) with the ewe under isoflurane\u2010opiate anesthesia. The mean occlusion time until cardiac arrest was 14.5 (4.2) min (SD). Lambs were immediately delivered and standardized resuscitation was instituted after 2 min asystole. At 4 hr postnatal age, [18\u2010F]Fluoro\u20102\u2010deoxy\u2010glucose (18\u2010FDG) was injected intravenously in eight asphyxiated lambs and in eight controls. Cerebral glucose metabolism was examined by positron emission tomography (PET). As a result the mean arterial blood pressure, acid\u2010base values, blood glucose and serum lactate at 4 hr postnatal age did not differ significantly between lambs subjected to umbilical cord occlusion and controls. EEG was abnormal in all lambs subjected to cord occlusion and normal in the controls at 4 hr postnatal age. Global cerebral metabolic rate (CMRgl) as determined by PET was significantly lower in lambs subjected to cord occlusion mean\/median (SD) 22.2\/19.6 (8.4) \u03bcmol\/min\/100 g) than in controls mean\/median (SD) 37.8\/35.9 (6.1);\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01). Global CMRgl is significantly reduced in newborn lambs 4 hr after fetal asphyxia induced by umbilical cord occlusion. A reduction in CMRgl is an early indicator of global hypoxic cerebral ischemia. \u00a9 2001 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/jnr.10051","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T12:24:03Z","timestamp":1030278243000},"page":"844-850","source":"Crossref","is-referenced-by-count":32,"title":["Reduced postnatal cerebral glucose metabolism measured by PET after asphyxia in near term fetal 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