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A few reports indicate that citicoline treatment may also be beneficial in glaucoma. Currently glaucoma is considered a neurodegenerative disease in which retinal ganglion cells (RGC) slowly die, likely in the apoptotic mechanism. Endogenous CDP\u2010choline is a natural precursor of cellular synthesis of phospholipids, mainly phosphatydylcholine (PtdCho). Enhancement of PtdCho synthesis may counteract neuronal apoptosis and provide neuroprotection. Citicoline, when administered, undergoes a quick transformation to cytidine and choline, which are believed to enter brain cells separately and provide neuroprotection by enhancing PtdCho synthesis; similar effect may be expected to occur in glaucomatous RGC. Furthermore, citicoline stimulates some brain neurotransmitter systems, including the dopaminergic system, and dopamine is known as a major neurotransmitter in retina and postretinal visual pathways. In a double\u2010blind, placebo\u2010controlled study, treatment of glaucoma resulted in functional improvement in the visual system noted with electrophysiological methods. Development of citicoline as a treatment for glaucoma is indicated. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.10129","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T12:30:43Z","timestamp":1030278643000},"page":"143-148","source":"Crossref","is-referenced-by-count":43,"title":["Pharmacodynamics of citicoline relevant to the treatment of glaucoma"],"prefix":"10.1002","volume":"67","author":[{"given":"Pawel","family":"Grieb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Rejdak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000117914"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1988.sp016951"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1358\/mf.1999.21.9.795632","article-title":"Double\u2010blind placebo\u2010controlled study with citicoline in APOE genotyped Alzheimer's disease patients. 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