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Constitutive expression of mRNA was detected for the NR\u20102A subunit in pituitary but not adrenal gland. Although on Western blotting assays adrenal medulla exhibited expression of NR\u20101 subunit protein without expression of NR\u20102C and NR\u20102D subunit proteins, an immunohistochemical investigation clearly showed selective localization of proteins for NR\u20101, NR\u20102C, and NR\u20102D subunits in adrenal medulla but not in adrenal cortex. Prior treatment with different glycosidases invariably resulted in a marked increase in immunoreactivity to the anti\u2010NR\u20101 antibody in both hippocampus and adrenal medulla. An intraperitoneal injection of a blocker of NMDA receptor channel, but not NMDA itself, led to marked potentiation of DNA binding activity of the transcription factor activator protein\u20101 in adrenal nuclear extracts 2 hr after administration. These results suggest that heteromeric NMDA receptor channels may be constitutively and functionally expressed with glycosylation of NR\u20101 subunit under the influence of tonic stimulation by circulating agonists such as L\u2010glutamate in rat adrenal medulla. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.10202","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:25:36Z","timestamp":1030317936000},"page":"36-45","source":"Crossref","is-referenced-by-count":16,"title":["Constitutive expression of heterologous N\u2010methyl\u2010D\u2010aspartate receptor subunits in rat adrenal 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