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The molecular mechanism underlying MKC\u2010242\u2010induced potentiation of this phase shift, however, has not yet been elucidated. We examined the effects of MKC\u2010242 on light\u2010induced <jats:italic>mPer1<\/jats:italic> and <jats:italic>mPer2<\/jats:italic> mRNA expression in the suprachiasmatic nucleus (SCN) of mice. MKC\u2010242 (5 mg kg<jats:sup>\u22121<\/jats:sup>, i.p.) potentiated light\u2010induced <jats:italic>mPer1<\/jats:italic> and <jats:italic>mPer2<\/jats:italic> expression in the SCN of mice housed in constant darkness for 2 days, when mRNA levels were observed 3 hr after light\u2010exposure. More potentiating action of MKC\u2010242 on <jats:italic>mPer2<\/jats:italic> expression in the SCN was observed in mice housed in constant darkness for 9\u201310 days. This facilitatory action of MKC\u2010242 on <jats:italic>mPer1<\/jats:italic> expression was antagonized by WAY100635, a selective 5\u2010HT<jats:sub>1A<\/jats:sub> receptor blocker, indicating that MKC\u2010242 activated 5\u2010HT<jats:sub>1A<\/jats:sub> receptors. Other drugs such as 8\u2010hydroxy\u2010dipropylaminotetralin (10 mg kg<jats:sup>\u22121<\/jats:sup>, i.p.), paroxetine (10 mg kg<jats:sup>\u22121<\/jats:sup>, i.p.), buspirone (10 mg kg<jats:sup>\u22121<\/jats:sup>, i.p.), and diazepam (10 mg kg<jats:sup>\u22121<\/jats:sup>, i.p.) did not display a potentiating action on light\u2010induced <jats:italic>mPer1<\/jats:italic> and <jats:italic>mPer2<\/jats:italic> expression in the SCN. In the behavioral experiments, we found that MKC\u2010242 (5 mg kg<jats:sup>\u22121<\/jats:sup>, i.p.) potentiated light\u2010induced phase delays of free\u2010running rhythm in mice. The present results suggest that prolonged increase of <jats:italic>mPer1<\/jats:italic> or <jats:italic>mPer2<\/jats:italic> expression in the SCN by MKC\u2010242 may be involved in the potentiation of photic entrainment by MKC\u2010242 in mice. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.10225","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:24:15Z","timestamp":1030317855000},"page":"470-478","source":"Crossref","is-referenced-by-count":20,"title":["Extended action of MKC\u2010242, a selective 5\u2010HT<sub>1A<\/sub> receptor agonist, on light\u2010induced <i>Per<\/i> gene expression in the suprachiasmatic nucleus in 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