{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:19:22Z","timestamp":1791137962129,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,4,30]],"date-time":"2002-04-30T00:00:00Z","timestamp":1020124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Accumulation of \u03b1\u2010synuclein has been associated with neurodegenerative disorders, such as Lewy body disease and multiple system atrophy. We previously showed that expression of wild\u2010type human \u03b1\u2010synuclein in transgenic mice results in motor and dopaminergic deficits associated with inclusion formation. To determine whether different levels of human \u03b1\u2010synuclein expression from distinct promoters might result in neuropathology mimicking other synucleopathies, we compared patterns of human \u03b1\u2010synuclein accumulation in the brains of transgenic mice expressing this molecule from the murine Thy\u20101 and platelet\u2010derived growth factor (PDGF) promoters. In murine Thy\u20101\u2010human \u03b1\u2010synuclein transgenic mice, this protein accumulated in synapses and neurons throughout the brain, including the thalamus, basal ganglia, substantia nigra, and brainstem. Expression of human \u03b1\u2010synuclein from the PDGF promoter resulted in accumulation in synapses of the neocortex, limbic system, and olfactory regions as well as formation of inclusion bodies in neurons in deeper layers of the neocortex. Furthermore, one of the intermediate expresser lines (line M) displayed human \u03b1\u2010synuclein expression in glial cells mimicking some features of multiple system atrophy. These results show a more widespread accumulation of human \u03b1\u2010synuclein in transgenic mouse brains. Taken together, these studies support the contention that human \u03b1\u2010synuclein expression in transgenic mice might mimic some neuropathological alterations observed in Lewy body disease and other synucleopathies, such as multiple system atrophy. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.10231","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:29:46Z","timestamp":1030318186000},"page":"568-578","source":"Crossref","is-referenced-by-count":482,"title":["Differential neuropathological alterations in transgenic mice expressing \u03b1\u2010synuclein from the platelet\u2010derived growth factor and Thy\u20101 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