{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T14:38:12Z","timestamp":1770475092592,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,6,27]],"date-time":"2002-06-27T00:00:00Z","timestamp":1025136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2002,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is anticipated that further understanding of the protective mechanism induced by ischemic preconditioning will improve prognosis for patients of ischemic injury. It is not known whether preconditioning exerts beneficial actions in neurodegenerative diseases, in which ischemic injury plays a causative role. Here we show that transient activation of ATP\u2010sensitive potassium channels, a trigger in ischemic preconditioning signaling, confers protection in PC12 cells and SH\u2010SY5Y cells against neurotoxic effect of rotenone and MPTP, mitochondrial complex I inhibitors that have been implicated in the pathogenesis of Parkinson's disease. The degree of protection is in proportion to the bouts of exposure to an ATP\u2010sensitive potassium channel opener, a feature reminiscent of ischemic tolerance in vivo. Protection is sensitive to a protein synthesis inhibitor, indicating the involvement of de novo protein synthesis in the protective processes. Pretreatment of PC12 cells with preconditioning stimuli FeSO<jats:sub>4<\/jats:sub> or xanthine\/xanthine oxidase also confers protection against rotenone\u2010induced cell death. Our results demonstrate for the first time the protective role of ATP\u2010sensitive potassium channels in a dopaminergic neuronal cell line against rotenone\u2010induced neurotoxicity and conceptually support the view that ischemic preconditioning\u2010derived therapeutic strategies may have potential and feasibility in therapy for Parkinson's disease. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.10309","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T11:44:15Z","timestamp":1033904655000},"page":"559-566","source":"Crossref","is-referenced-by-count":38,"title":["Activation of adenosine triphosphate\u2010sensitive potassium channels confers protection against rotenone\u2010induced cell death: Therapeutic implications for Parkinson's disease"],"prefix":"10.1002","volume":"69","author":[{"given":"Kwok\u2010Keung","family":"Tai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel 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