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The cotton wool type plaques were related to extremely high production of A\u03b242, due mainly to presenilin 1 mutations and low immune responses. Cotton wool plaques were numerous in the entire central nervous system, including basal ganglia, brainstem and even in spinal cord. Cotton wool type plaques were composed of slightly electron dense synaptic structures, but amyloid fibrils were rarely found. Such a high accumulation of A\u03b242 may cause degeneration of the pyramidal tract and basal ganglia from an early stage of Alzheimer's disease. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.10392","type":"journal-article","created":{"date-parts":[[2002,10,22]],"date-time":"2002-10-22T14:37:14Z","timestamp":1035297434000},"page":"367-372","source":"Crossref","is-referenced-by-count":48,"title":["Alzheimer's disease with spastic paresis and cotton wool type plaques"],"prefix":"10.1002","volume":"70","author":[{"given":"Takeshi","family":"Tabira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De Hua","family":"Chui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigetoshi","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Shibuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,10,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/78682"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2001-3208"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0498-452"},{"key":"e_1_2_6_5_1","first-page":"417","article-title":"Alzheimer's disease in identical twin brothers: investigations of their family history and of clinical development of the disease","volume":"86","author":"Doi A","year":"1984","journal-title":"Seishin shinkeigaku zasshi"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.5.801"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200011)48:5<806::AID-ANA18>3.0.CO;2-F"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199704140-00043"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/60.11.1051"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2990.2001.00316.x"},{"key":"e_1_2_6_11_1","first-page":"801","article-title":"A case of encephalopathy with plaque\u2010like bodies, neurofibrillary change, angiopathy and amyotrophic lateral sclerosis\u2010like lesions","volume":"11","author":"Matsuoka T","year":"1967","journal-title":"Adv Neurol Sci (Tokyo)"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(01)00289-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410430217"},{"key":"e_1_2_6_14_1","first-page":"206","article-title":"Early onset Alzheimer's disease? 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