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Na<jats:sub>v<\/jats:sub>1.3\/brain type III sodium channel expression is up\u2010regulated following peripheral axotomy of dorsal root ganglion (DRG) and facial motor neurons, but, to date, Na<jats:sub>v<\/jats:sub>1.3 expression has not been examined in upper (cortical) motor neurons following axotomy associated with SCI. In the present study, we examine Na<jats:sub>v<\/jats:sub>1.3 expression in upper motor neurons within rat primary motor cortex following midthoracic (T9) dorsal column transection, which severs the axons of those cells. Axotomized pyramidal cells were identified by retrograde transport of fluorogold. Immunolabeled cells were confined to layer V of the primary motor cortex and exhibited low levels of Na<jats:sub>v<\/jats:sub>1.3 staining. After axotomy, no significant changes were detected in Na<jats:sub>v<\/jats:sub>1.3 density or distribution in injured or uninjured cells, compared with control brains, in contrast to up\u2010regulation of Na<jats:sub>v<\/jats:sub>1.3 in ipsilateral DRG neurons after sciatic nerve transection. These results do not preclude a role for voltage\u2010gated sodium channels in post\u2010SCI epilepsy but suggest that up\u2010regulated expression of Na<jats:sub>v<\/jats:sub>1.3 channel is not involved. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.10402","type":"journal-article","created":{"date-parts":[[2002,10,29]],"date-time":"2002-10-29T13:59:29Z","timestamp":1035899969000},"page":"546-552","source":"Crossref","is-referenced-by-count":21,"title":["Primary motor neurons fail to up\u2010regulate voltage\u2010gated sodium channel Na<sub>v<\/sub>1.3\/brain type III following axotomy resulting from spinal cord injury"],"prefix":"10.1002","volume":"70","author":[{"given":"Bryan C.","family":"Hains","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel A.","family":"Black","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen 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