{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:31:06Z","timestamp":1759048266990},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,4,3]],"date-time":"2001-04-03T00:00:00Z","timestamp":986256000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2001,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Relapsing experimental allergic encephalomyelitis (EAE) was induced in DA rats and the ocular pathologic events were examined at the various phases of the illness. About 80% of EAE rats presented anterior uveitis (AU), even after complete EAE recovery. We studied the phenotype and localization of immunocompetent cells, the major histocompatibility complex (MHC) class I and II antigen expression, as well as the chemokine monocyte chemoattractant protein\u20101 (MCP\u20101) appearance. In control animals, there were many glial fibrillary acidic protein (GFAP)<jats:sup>+<\/jats:sup> cells and OX42<jats:sup>+<\/jats:sup> cells in the ciliary body, retina, optic nerve and chiasma. Except in retina, we observed constitutive MHC class I and II expression. During the EAE acute phase, there was up\u2010regulation of MHC class II and GFAP antigens in iris, ciliary body, limbus, and optic pathways. MHC class I and ED2 antigens were expressed in meninges and in the prechiasmatic cisterna, by cells which could have a role in immune surveillance. MCP\u20101 mRNA was highly expressed in optic pathways during the acute phase and the protein was expressed by astrocytes, macrophages, and lymphocytes. During the relapsing phase, MCP\u20101 was weakly expressed to disappear almost completely during the final recovery phase. The expression of MHC class II on astrocytes was increased during the relapsing and final recovery phase in which the inflammatory lesions persisted. These findings suggest that ocular areas and optic pathways, mainly optic chiasma, are important targets in the relapsing EAE. J. Neurosci. Res. 63:525\u2013535, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.1047","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T18:04:33Z","timestamp":1030298673000},"page":"525-535","source":"Crossref","is-referenced-by-count":8,"title":["Distribution in ocular structures and optic pathways of immunocompetent and glial cells in an experimental allergic encephalomyelitis (EAE) relapsing model"],"prefix":"10.1002","volume":"63","author":[{"given":"Henri","family":"Villarroya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Thillaye\u2010Goldenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Eclancher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,4,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19960615)44:6<513::AID-JNR1>3.0.CO;2-E"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19971115)50:4<531::AID-JNR4>3.0.CO;2-F"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(93)90053-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.4049\/jimmunol.156.8.3017","article-title":"Localization of monocyte chemoattractant peptide\u20101. 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