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Here we demonstrate that glial cells up\u2010regulate expression of CHL1 in response to an intraorbital crush of the adult mouse optic nerve. We also demonstrate that a single intravitreal application of fibroblast growth factor\u20102 (FGF\u20102) increases expression of CHL1 in retinal astrocytes and M\u00fcller cells. Elevated expression of CHL1 by glial cells in injured optic nerves and astrocytes and M\u00fcller cells in FGF\u20102\u2010treated retinas suggests a role of the protein in the lesioned central nervous system. Results also suggest that trophic factors might exert part of their biological function by modifying expression of cell recognition molecules. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.10533","type":"journal-article","created":{"date-parts":[[2003,3,18]],"date-time":"2003-03-18T23:07:03Z","timestamp":1048028823000},"page":"835-843","source":"Crossref","is-referenced-by-count":23,"title":["Altered expression of CHL1 by glial cells in response to optic nerve injury and intravitreal application of fibroblast growth 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