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The right facial nerves of adult Fischer 344 male rats were avulsed and removed from the stylomastoid foramen, and adenoviral vectors were injected into the facial canal. Animals avulsed and treated with adenovirus encoding GDNF, BDNF, CNTF, CT1, IGF1 and TGF\u03b22 showed intense immunolabeling for these factors in lesioned facial motoneurons, respectively, indicating adenoviral induction of the neurotrophic factors in these neurons. The treatment with adenovirus encoding GDNF, BDNF, or TGF\u03b22 after avulsion significantly prevented the loss of lesioned facial motoneurons, improved choline acetyltransferase immunoreactivity and prevented the induction of nitric oxide synthase activity in these neurons. The treatment with adenovirus encoding CNTF, CT1 or IGF1, however, failed to protect these neurons after avulsion. These results indicate that the gene transfer of GDNF and BDNF and TGF\u03b22 but not CNTF, CT1 or IGF1 may prevent the degeneration of motoneurons in adult humans with motoneuron injury and motor neuron diseases. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.10558","type":"journal-article","created":{"date-parts":[[2003,3,14]],"date-time":"2003-03-14T17:02:46Z","timestamp":1047661366000},"page":"54-64","source":"Crossref","is-referenced-by-count":73,"title":["Adenoviral gene transfer of GDNF, BDNF and TGF\u03b22, but not CNTF, cardiotrophin\u20101 or IGF1, protects injured adult motoneurons after facial nerve 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