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We examined the influence of extracts (postmicrosomal fractions) obtained from non\u2010pre\u2010degenerated or 7\u2010day\u2010pre\u2010degenerated distal segments of peripheral nerves on the regeneration of injured sciatic nerves of male adult rats. The extracts were introduced to the site of injury with autologous connective tissue chambers filled with fibrin. Reference groups were treated with brain\u2010derived neurotrophic factor (BDNF) or fibrin only. We examined DiI\u2010labeled motoneurons, toluidine blue\u2010labeled myelinated fibers in the mid\u2010part of the chambers, and AChE\u2010positive nerve endings to assess the regeneration intensity. In addition, the length of fibers regrowing within the chambers was measured. We found that extracts obtained from distal stumps of 7\u2010day\u2010pre\u2010degenerated peripheral nerves enhanced nerve regeneration as strongly as BDNF. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.10560","type":"journal-article","created":{"date-parts":[[2003,4,9]],"date-time":"2003-04-09T10:01:46Z","timestamp":1049882506000},"page":"417-424","source":"Crossref","is-referenced-by-count":19,"title":["Regeneration of sciatic nerves of adult rats induced by extracts from distal stumps of pre\u2010degenerated peripheral 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